PMID- 9952039
OWN - NLM
STAT- MEDLINE
DCOM- 19990413
LR  - 20190726
IS  - 0033-3158 (Print)
IS  - 0033-3158 (Linking)
VI  - 141
IP  - 2
DP  - 1999 Jan
TI  - Locomotor response to MDMA is attenuated in knockout mice lacking the 5-HT1B 
      receptor.
PG  - 154-61
AB  - 3,4-Methylenedioxymethamphetamine (MDMA) is a psychoactive drug of abuse which is 
      increasingly popular in human recreational drug use. In rats, the drug has been 
      shown to stimulate locomotion while decreasing exploratory behavior. MDMA acts as 
      an indirect agonist of serotonin (5-HT) receptors by inducing 5-HT release by a 
      5-HT reuptake transporter-dependent mechanism, although it is not known which 
      5-HT receptors are important for the behavioral effects of the drug. In order to 
      examine the role of specific 5-HT receptors, we assessed the behavioral effects 
      of MDMA on knockout mice lacking the 5-HT1B receptor. Knockout animals show a 
      reduced locomotor response to MDMA, although delayed locomotor stimulation is 
      present in these animals. This finding indicates that the locomotor effects of 
      MDMA are dependent upon the 5-HT1B receptor, at least in part. In contrast, MDMA 
      eliminates exploratory behavior in both normal and knockout mice, suggesting that 
      the exploratory suppression induced by MDMA occurs through mechanisms other than 
      activation of the 5-HT1B receptor. To confirm these findings, we tested the 
      effects of MDMA on the locomotor and exploratory behavior of wild-type mice 
      pretreated with GR 127935, a 5-HT1B/1D receptor antagonist. These mice had an 
      attenuated locomotor response to MDMA, but still exhibited the drug-induced 
      suppression of exploration.
FAU - Scearce-Levie, K
AU  - Scearce-Levie K
AD  - Center for Neurobiology and Behavior, Columbia Unversity, New York, NY 10032, 
      USA.
FAU - Viswanathan, S S
AU  - Viswanathan SS
FAU - Hen, R
AU  - Hen R
LA  - eng
GR  - R01DA09862/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Germany
TA  - Psychopharmacology (Berl)
JT  - Psychopharmacology
JID - 7608025
RN  - 0 (HTR1B protein, human)
RN  - 0 (Receptor, Serotonin, 5-HT1B)
RN  - 0 (Receptors, Serotonin)
RN  - 0 (Serotonin Agents)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Animals
MH  - Exploratory Behavior/drug effects/physiology
MH  - Humans
MH  - Mice
MH  - Mice, Knockout
MH  - Motor Activity/*drug effects/physiology
MH  - N-Methyl-3,4-methylenedioxyamphetamine/*pharmacology
MH  - Rats
MH  - Receptor, Serotonin, 5-HT1B
MH  - Receptors, Serotonin/deficiency/*physiology
MH  - Serotonin Agents/*pharmacology
EDAT- 1999/02/10 00:00
MHDA- 1999/02/10 00:01
CRDT- 1999/02/10 00:00
PHST- 1999/02/10 00:00 [pubmed]
PHST- 1999/02/10 00:01 [medline]
PHST- 1999/02/10 00:00 [entrez]
AID - 10.1007/s002130050819 [doi]
PST - ppublish
SO  - Psychopharmacology (Berl). 1999 Jan;141(2):154-61. doi: 10.1007/s002130050819.