PMID- 9952272
OWN - NLM
STAT- MEDLINE
DCOM- 19990216
LR  - 20190813
IS  - 0013-9580 (Print)
IS  - 0013-9580 (Linking)
VI  - 40
IP  - 2
DP  - 1999 Feb
TI  - Family studies and human leukocyte antigen class II typing in Indian probands 
      with seizures in association with single small enhancing computed tomography 
      lesions.
PG  - 232-8
AB  - PURPOSE: To define the clinical features of the syndrome of seizures associated 
      with single, small, enhancing computed tomography (CT) lesions (SSELs) in 235 
      Indian probands and seizure types among their family members. Human leukocyte 
      antigen (HLA) class II genomic typing in randomly selected 41 probands was done 
      to identify the role of hereditary factors in this syndrome. METHODS: The seizure 
      types among 235 probands, their clinical outcome, and seizures in their family 
      members were studied. Family data were collected on relatives of 212 additional 
      probands with neurologic diseases other than epilepsy. HLA class II antigens were 
      studied by using polymerase chain reaction (PCR) amplified DNA and 
      sequence-specific oligonucleotide probe (PCR-SSOP) hybridization. RESULTS: The 
      seizures in 86% were partial with or without generalization; 77% had fewer than 
      five seizures before the first CT scan. Evanescent focal neurologic deficits 
      after seizures were noted in 40%. Most patients (97%) were treated with a single 
      antiepileptic drug (AED). Significant resolution of the CT scan lesion was noted 
      within 6 months in 125 (53%) of 235 cases. Two thirds of patients had no seizures 
      while taking a single AED, and an additional 18% had no seizures even after their 
      AEDs were discontinued. Epilepsy among relatives of Indian probands having 
      seizures in association with SSELs was more common as compared with relatives of 
      probands with other neurologic diseases. A family history of seizures was noted 
      in 21% probands, the ratio of affected first- to second-degree relatives was 
      4.3:1, and 60% of affected sibs had syndromic concordance with probands. There 
      was a positive association of HLA-DRB1*13 (Pc = 0.036) with this syndrome. 
      CONCLUSIONS: The syndrome of seizures in association with SSELs seems to be a 
      benign localization-related epileptic syndrome. Our results of HLA studies point 
      to an inherited susceptibility to an infective agent, which in most cases is of 
      cysticercal etiology.
FAU - Jain, S
AU  - Jain S
AD  - Department of Neurology, All India Institute of Medical Sciences, New Delhi.
FAU - Padma, M V
AU  - Padma MV
FAU - Kanga, U
AU  - Kanga U
FAU - Mehra, N K
AU  - Mehra NK
FAU - Puri, A
AU  - Puri A
FAU - Maheshwari, M C
AU  - Maheshwari MC
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Epilepsia
JT  - Epilepsia
JID - 2983306R
RN  - 0 (Anticonvulsants)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Oligonucleotide Probes)
SB  - IM
MH  - Adult
MH  - Anticonvulsants/therapeutic use
MH  - Central Nervous System Diseases/diagnostic imaging/epidemiology
MH  - Comorbidity
MH  - Epilepsies, Partial/diagnostic imaging/epidemiology/genetics
MH  - *Family
MH  - Female
MH  - Frontal Lobe/*diagnostic imaging
MH  - HLA-DR Antigens/genetics
MH  - HLA-DRB1 Chains
MH  - Histocompatibility Antigens Class II/*genetics
MH  - Humans
MH  - India/epidemiology
MH  - Male
MH  - Molecular Sequence Data
MH  - Oligonucleotide Probes
MH  - Polymerase Chain Reaction
MH  - Seizures/*diagnostic imaging/epidemiology/*genetics
MH  - *Tomography, X-Ray Computed
EDAT- 1999/02/10 00:00
MHDA- 1999/02/10 00:01
CRDT- 1999/02/10 00:00
PHST- 1999/02/10 00:00 [pubmed]
PHST- 1999/02/10 00:01 [medline]
PHST- 1999/02/10 00:00 [entrez]
AID - 10.1111/j.1528-1157.1999.tb02080.x [doi]
PST - ppublish
SO  - Epilepsia. 1999 Feb;40(2):232-8. doi: 10.1111/j.1528-1157.1999.tb02080.x.