PMID- 9972411
OWN - NLM
STAT- MEDLINE
DCOM- 19990414
LR  - 20190826
IS  - 0004-8291 (Print)
IS  - 0004-8291 (Linking)
VI  - 28
IP  - 6
DP  - 1998 Dec
TI  - Percutaneous transseptal mitral valvotomy--progress report.
PG  - 805-10
AB  - BACKGROUND: Percutaneous transseptal mitral valvotomy (PTMV) has been established 
      as an alternative to surgery in the treatment of mitral stenosis. AIM: To review 
      our experience in the first 200 attempted PTMV procedures in patients with mitral 
      stenosis, and the short and medium term follow-up. METHODS: PTMV was attempted on 
      200 occasions in 189 patients with significant mitral stenosis between May 1988 
      and May 1994. There were 156 females and 33 males, mean age 53.5 years (range 14 
      to 83 years). Six patients were pregnant at the time of the procedure. RESULTS: 
      Valve split was achieved at the initial attempt in 183/189 procedures (97%). 
      Clinical improvement of at least one New York Heart Association (NYHA) functional 
      class was achieved in 172/189 patients (91%). The mean mitral valve gradient 
      (mean +/- SD) decreased from 11.5 +/- 5.1 mmHg to 4.9 +/- 4.1 mmHg, mean cardiac 
      output rose from 3.9 +/- 1.1 L/minute to 4.4 +/- 1.4 L/minute and mean calculated 
      mitral valve area increased from 1.0 +/- 0.3 cm2 to 2.1 +/- 0.9 cm2. Ten patients 
      developed clinically significant mitral incompetence requiring surgical mitral 
      valve replacement. There were two transient cerebral embolic events. Small atrial 
      septal defects were detected echocardiographically in 42 patients, but none has 
      been a clinical problem. There were no early deaths; there were 11 late deaths, 
      four of which were non-cardiac. Twenty patients have had repeat PTMV for 
      re-stenosis, four to 67 months after the first. CONCLUSIONS: PTMV provides 
      significant haemodynamic and clinical improvement with low risk and should be 
      considered the treatment of choice in patients with mitral stenosis.
FAU - McCredie, R M
AU  - McCredie RM
AD  - Eastern Heart Clinic, Prince Henry Hospital, Sydney, NSW.
FAU - Allan, R M
AU  - Allan RM
FAU - Hill, A T
AU  - Hill AT
FAU - Black, I W
AU  - Black IW
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Aust N Z J Med
JT  - Australian and New Zealand journal of medicine
JID - 1264322
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Catheterization/adverse effects/*methods
MH  - Echocardiography
MH  - Female
MH  - Hemodynamics
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mitral Valve Stenosis/diagnostic imaging/*therapy
MH  - Pregnancy
MH  - Pregnancy Complications, Cardiovascular/therapy
MH  - Survival Analysis
MH  - Treatment Outcome
EDAT- 1999/02/11 00:00
MHDA- 1999/02/11 00:01
CRDT- 1999/02/11 00:00
PHST- 1999/02/11 00:00 [pubmed]
PHST- 1999/02/11 00:01 [medline]
PHST- 1999/02/11 00:00 [entrez]
AID - 10.1111/j.1445-5994.1998.tb01558.x [doi]
PST - ppublish
SO  - Aust N Z J Med. 1998 Dec;28(6):805-10. doi: 10.1111/j.1445-5994.1998.tb01558.x.