PMID- 9972507
OWN - NLM
STAT- MEDLINE
DCOM- 19990414
LR  - 20191102
IS  - 0265-2048 (Print)
IS  - 0265-2048 (Linking)
VI  - 16
IP  - 1
DP  - 1999 Jan-Feb
TI  - Biodegradable poly(DL-lactic-co-glycolic acid) microspheres containing tetracaine 
      hydrochloride. In-vitro release profile.
PG  - 105-15
AB  - Tetracaine does not result in effective treatment of intractable pain caused by 
      trigeminal neuralgia because of its short duration of effect. In a sustained 
      release system a controlled delivery of the drug at the site of administration, 
      would avoid successive administrations. Tetracaine hydrochloride (HCl) has been 
      encapsulated using a technique based on the evaporation of solvent from an O/O 
      emulsion, using poly(DL-lactic-co-glycolic acid) (PLGA) 50:50. Microspheres were 
      separated into three fractions: 106-212, 212-300 and 300-425 microns. The effects 
      of two variables of the manufacturing method (volume of the inner phase of the 
      emulsion and volume of surfactant added to the external phase) on the drug 
      loading into microspheres, dissolution profiles and SEM characterization of the 
      microspheres were evaluated. Microspheres containing tetracaine hydrochloride (up 
      to 94% referred to the theoretical) released the drug, in-vitro, over 35 days. 
      Tetracaine HCl was delivered according to zero order kinetics from day 5 until 
      the end of the release assay. The rate of drug release depended mainly on the 
      viscosity of the discontinuous phase and on the size of microparticles. 
      Microsphere size resulted more homogeneous when using the highest volume of the 
      surfactant, being almost 80% of microparticles within the range 212-300 microns.
FAU - Ramirez, L
AU  - Ramirez L
AD  - Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, 
      Complutense University, Madrid, Spain.
FAU - Pastoriza, P
AU  - Pastoriza P
FAU - Herrero-Vanrell, R
AU  - Herrero-Vanrell R
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Microencapsul
JT  - Journal of microencapsulation
JID - 8500513
RN  - 0 (Anesthetics, Local)
RN  - 0 (Delayed-Action Preparations)
RN  - 0 (Polymers)
RN  - 059QF0KO0R (Water)
RN  - 0619F35CGV (Tetracaine)
RN  - 1SIA8062RS (Polylactic Acid-Polyglycolic Acid Copolymer)
RN  - 26009-03-0 (Polyglycolic Acid)
RN  - 33X04XA5AT (Lactic Acid)
SB  - IM
MH  - Anesthetics, Local/*chemistry/pharmacology
MH  - Biodegradation, Environmental
MH  - Chemistry, Pharmaceutical/methods
MH  - Delayed-Action Preparations
MH  - Kinetics
MH  - Lactic Acid/*chemistry
MH  - Microspheres
MH  - Polyglycolic Acid/*chemistry
MH  - Polylactic Acid-Polyglycolic Acid Copolymer
MH  - Polymers/*chemistry
MH  - Solubility
MH  - Tetracaine/*chemistry/pharmacology
MH  - Water/chemistry
EDAT- 1999/02/11 00:00
MHDA- 1999/02/11 00:01
CRDT- 1999/02/11 00:00
PHST- 1999/02/11 00:00 [pubmed]
PHST- 1999/02/11 00:01 [medline]
PHST- 1999/02/11 00:00 [entrez]
AID - 10.1080/026520499289356 [doi]
PST - ppublish
SO  - J Microencapsul. 1999 Jan-Feb;16(1):105-15. doi: 10.1080/026520499289356.