PMID- 9972790
OWN - NLM
STAT- MEDLINE
DCOM- 19990224
LR  - 20190909
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 75
IP  - 1
DP  - 1999 Jan
TI  - S values are not a signature for a significant contribution of neutrons to the 
      radiation dose received by atomic-bomb survivors.
PG  - 47-9
AB  - PURPOSE: It has been proposed previously that the ratio of complete to incomplete 
      translocations as seen by fluorescence in situ hybridization (FISH), the S value, 
      can be a cytogenetic fingerprint of exposure to radiation of different qualities. 
      Results from a previous study suggested that the S value is approximately 10 for 
      sparsely ionizing radiations such as X- and gamma-rays, and 2 for densely 
      ionizing radiations. Based on FISH data of atomic-bomb (A-bomb) survivors, which 
      showed an S value of 3.25, a significant neutron component to A-bomb radiation 
      was suggested. To examine the possibility, the present in vitro study was 
      conducted using X-rays. MATERIALS AND METHODS: Human blood lymphocytes were 
      exposed to X-rays and first metaphases were examined with FISH using DNA probes 
      for chromosomes 1, 2 and 4. RESULTS: The S value was 3.16 for X-rays, which 
      differs from approximately 10 as reported previously, and not larger than the 
      3.25 obtained from the blood lymphocytes of A-bomb survivors. CONCLUSIONS: S 
      values seem to vary among laboratories even after exposure of cells to sparsely 
      ionizing radiations. Data from this study show that S values are not a signature 
      for a significant contribution of neutrons to the radiation dose received by 
      A-bomb survivors in Hiroshima.
FAU - Nakano, M
AU  - Nakano M
AD  - Department of Genetics, Radiation Effects Research Foundation, Hiroshima, Japan. 
      nakano@rerf.or.jp
FAU - Kodama, Y
AU  - Kodama Y
FAU - Ohtaki, K
AU  - Ohtaki K
FAU - Itoh, M
AU  - Itoh M
FAU - Nakamura, N
AU  - Nakamura N
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - *Chromosome Breakage
MH  - Dose-Response Relationship, Radiation
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Japan
MH  - *Neutrons
MH  - Nuclear Warfare
MH  - *Radiation Dosage
MH  - Sensitivity and Specificity
MH  - Survivors
EDAT- 1999/02/11 00:00
MHDA- 1999/02/11 00:01
CRDT- 1999/02/11 00:00
PHST- 1999/02/11 00:00 [pubmed]
PHST- 1999/02/11 00:01 [medline]
PHST- 1999/02/11 00:00 [entrez]
AID - 10.1080/095530099140799 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 1999 Jan;75(1):47-9. doi: 10.1080/095530099140799.