PMID- 9972980
OWN - NLM
STAT- MEDLINE
DCOM- 19990630
LR  - 20131121
IS  - 0315-162X (Print)
IS  - 0315-162X (Linking)
VI  - 26
IP  - 2
DP  - 1999 Feb
TI  - Interleukin 8 and monocyte chemoattractant protein-1 in patients with juvenile 
      rheumatoid arthritis. Relation to onset types, disease activity, and synovial 
      fluid leukocytes.
PG  - 425-31
AB  - OBJECTIVE: To measure serum and synovial fluid (SF) levels of interleukin 8 
      (IL-8) and monocyte chemoattractant protein-1 (MCP-1) in patients with juvenile 
      rheumatoid arthritis (JRA) and to compare them with adult rheumatoid 
      factor-positive rheumatoid arthritis (RA). METHODS: IL-8 and MCP-1 were measured 
      by immunoassay (1) in sera obtained from 55 children with JRA and from 16 adults 
      with RA, and (2) in SF obtained from 30 children with JRA and 11 adults with RA. 
      RESULTS: Patients with active systemic JRA had serum levels of IL-8 and MCP-1 
      higher than in controls (p<0.01) and in patients with active polyarticular or 
      pauciarticular JRA (p<0.05). In patients with RA serum MCP-1 levels were higher 
      than in patients with the 3 JRA onset types, while no difference was found for 
      IL-8 levels. Patients with systemic JRA and with current systemic features had 
      serum levels of IL-8 and MCP-1 higher (p = 0.03 and p = 0.04, respectively) than 
      patients in which systemic features had subsided. No significant differences in 
      SF IL-8 or MCP-1 levels were found among the 3 JRA onset types or adults with RA. 
      In patients with JRA SF leukocyte counts were correlated with SF IL-8 levels (p = 
      0.002), but not with MCP-1 levels. Moreover, SF levels of both IL-8 and MCP-1 
      were correlated with those of IL-1beta (p<0.001) and IL-6 (p<0.01), but not with 
      those of TNF-alpha. CONCLUSION: Elevated serum levels of IL-8 and MCP-1 in 
      patients with systemic JRA with current systemic features at sampling suggest 
      systemic production of the 2 chemokines during systemic phases of the disease. 
      Similar SF levels of IL-8 and MCP-1 among the 3 JRA onset-types and RA suggest 
      comparable local production of the 2 chemokines.
FAU - De Benedetti, F
AU  - De Benedetti F
AD  - Clinica Pediatrica dell'Universita', Dipartimento assistenziale di Medicina 
      Interna e Nefrologia, IRCCS Policlinico San Matteo, Pavia, Italy.
FAU - Pignatti, P
AU  - Pignatti P
FAU - Bernasconi, S
AU  - Bernasconi S
FAU - Gerloni, V
AU  - Gerloni V
FAU - Matsushima, K
AU  - Matsushima K
FAU - Caporali, R
AU  - Caporali R
FAU - Montecucco, C M
AU  - Montecucco CM
FAU - Sozzani, S
AU  - Sozzani S
FAU - Fantini, F
AU  - Fantini F
FAU - Martini, A
AU  - Martini A
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PL  - Canada
TA  - J Rheumatol
JT  - The Journal of rheumatology
JID - 7501984
RN  - 0 (Chemokine CCL2)
RN  - 0 (Interleukin-1)
RN  - 0 (Interleukin-6)
RN  - 0 (Interleukin-8)
RN  - 0 (Receptors, Tumor Necrosis Factor)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Age of Onset
MH  - Aged
MH  - Arthritis, Juvenile/*blood/*diagnosis/pathology
MH  - Arthritis, Rheumatoid/blood/diagnosis/pathology
MH  - Blood Sedimentation
MH  - Chemokine CCL2/*analysis/blood
MH  - Child
MH  - Child, Preschool
MH  - Humans
MH  - Interleukin-1/analysis
MH  - Interleukin-6/analysis
MH  - Interleukin-8/*analysis/blood
MH  - Leukocyte Count
MH  - Middle Aged
MH  - Receptors, Tumor Necrosis Factor/analysis
MH  - Synovial Fluid/*chemistry/cytology
MH  - Tumor Necrosis Factor-alpha/analysis
EDAT- 1999/02/11 00:00
MHDA- 1999/02/11 00:01
CRDT- 1999/02/11 00:00
PHST- 1999/02/11 00:00 [pubmed]
PHST- 1999/02/11 00:01 [medline]
PHST- 1999/02/11 00:00 [entrez]
PST - ppublish
SO  - J Rheumatol. 1999 Feb;26(2):425-31.