PMID- 9973035
OWN - NLM
STAT- MEDLINE
DCOM- 19990302
LR  - 20190708
IS  - 0735-1097 (Print)
IS  - 0735-1097 (Linking)
VI  - 33
IP  - 2
DP  - 1999 Feb
TI  - Relationship between endothelin-1 extraction in the peripheral circulation and 
      systemic vascular resistance in patients with severe congestive heart failure.
PG  - 530-7
AB  - OBJECTIVES: This study was done to determine the spillover and extraction of 
      endothelin-1 (ET-1) in the peripheral circulation, and to evaluate the factors 
      that regulate local ET-1 extraction in the peripheral circulation in patients 
      with congestive heart failure (CHF). BACKGROUND: The relationship between the 
      spillover and extraction of the ET-1 in the peripheral circulation and systemic 
      vascular resistance (SVR) has not been fully clarified. METHODS: We measured 
      plasma levels of ET-1 both in femoral artery (FA) and femoral vein (FV) in 93 
      patients with CHF. RESULTS: Plasma ET-1 was significantly higher in FV than in FA 
      in New York Heart Association (NYHA) functional class II patients, but there was 
      no difference of ET-1 between FA and FV in functional class III patients. In 
      patients with functional class IV, plasma ET-1 was significantly lower in FV than 
      in FA, and SVR was significantly higher than in patients with NYHA class II or 
      class III. Moreover, a significant positive correlation existed between plasma 
      ET-1 extraction across the lower leg and SVR in these patients. Among the various 
      neurohumoral factors and hemodynamics, plasma levels of ET-1, angiotensin II in 
      the FA showed an independent and significant relationship with the plasma 
      arteriovenous difference of ET-1 in the lower limb. CONCLUSIONS: Circulating ET-1 
      is extracted in peripheral circulation in patients with severe CHF, suggesting 
      the possibility of upregulation of ET receptors of vascular beds in the lower 
      limb in these patients. The peripheral extraction of ET-1 correlates with SVR in 
      severe CHF patients and is mainly regulated by the local ET-1 and renin 
      angiotensin systems.
FAU - Tsutamoto, T
AU  - Tsutamoto T
AD  - First Department of Internal Medicine, Shiga University of Medical Science, Seta, 
      Otsu, Japan. tutamoto@belle.shiga-med.ac.jp
FAU - Wada, A
AU  - Wada A
FAU - Hisanaga, T
AU  - Hisanaga T
FAU - Maeda, K
AU  - Maeda K
FAU - Ohnishi, M
AU  - Ohnishi M
FAU - Mabuchi, N
AU  - Mabuchi N
FAU - Sawaki, M
AU  - Sawaki M
FAU - Hayashi, M
AU  - Hayashi M
FAU - Fujii, M
AU  - Fujii M
FAU - Kinoshita, M
AU  - Kinoshita M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Am Coll Cardiol
JT  - Journal of the American College of Cardiology
JID - 8301365
RN  - 0 (Angiotensin-Converting Enzyme Inhibitors)
RN  - 0 (Biomarkers)
RN  - 0 (Endothelin-1)
RN  - 11128-99-7 (Angiotensin II)
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
RN  - 85637-73-6 (Atrial Natriuretic Factor)
RN  - X4W3ENH1CV (Norepinephrine)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Angiotensin II/blood
MH  - Angiotensin-Converting Enzyme Inhibitors/therapeutic use
MH  - Atrial Natriuretic Factor/blood
MH  - Biomarkers/blood
MH  - Blood Pressure
MH  - Endothelin-1/*blood
MH  - Female
MH  - Femoral Artery
MH  - Femoral Vein
MH  - Heart Failure/*blood/drug therapy/physiopathology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/blood
MH  - Norepinephrine/blood
MH  - Pulmonary Wedge Pressure
MH  - Severity of Illness Index
MH  - *Vascular Resistance
EDAT- 1999/02/11 00:00
MHDA- 1999/02/11 00:01
CRDT- 1999/02/11 00:00
PHST- 1999/02/11 00:00 [pubmed]
PHST- 1999/02/11 00:01 [medline]
PHST- 1999/02/11 00:00 [entrez]
AID - S0735-1097(98)00573-7 [pii]
AID - 10.1016/s0735-1097(98)00573-7 [doi]
PST - ppublish
SO  - J Am Coll Cardiol. 1999 Feb;33(2):530-7. doi: 10.1016/s0735-1097(98)00573-7.