PMID- 9973918
OWN - NLM
STAT- MEDLINE
DCOM- 19990225
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 108
IP  - 1
DP  - 1999 Jan 1
TI  - Biclonal chromosomal aberrations in a child with myelodysplastic syndrome.
PG  - 13-8
AB  - Hematological malignancies and premalignant diseases are generally of monoclonal 
      origin. The prognostic and therapeutic significance of finding two genetically 
      independent clones remains to be determined. We followed a case of childhood 
      myelodysplastic syndrome showing biclonal chromosomal abnormalities (+8, -7) by 
      conventional cytogenetic examination and double target fluorescence in situ 
      hybridization (FISH). A 7-year-old girl presented with Plaut-Vincent angina and 
      leukopenia. The cytogenetic aberration of +8 was the first sign to suggest MDS. 
      Serial bone marrow controls, prompted by a progressive clinical course detected 
      myelodysplastic changes and a new clonal aberration (-7). The presence of -7 and 
      +8 in two independent clones was verified by double-target FISH. While at 
      diagnosis and during cytokine treatment more cells showed +8, after successful 
      all-trans retinoic acid (ATRA) therapy, the clone with -7 predominated. Following 
      allogeneic bone marrow transplantation the patient displayed donor-derived 
      hematopoesis. Our data stress the significance of cytogenetic and FISH 
      examinations in detecting specific genetic abnormalities and progressive clonal 
      changes as an indicator and guideline for therapy. Different cell clones 
      characterized by different genetic changes might be associated with different 
      biologic features reflected in their response to treatment.
FAU - Jakab, Z
AU  - Jakab Z
AD  - Department of Pediatrics, University Medical School, Debrecen, Hungary.
FAU - Balogh, E
AU  - Balogh E
FAU - Kiss, C
AU  - Kiss C
FAU - Pajor, L
AU  - Pajor L
FAU - Olah, E
AU  - Olah E
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Angina Pectoris
MH  - Biopsy, Needle
MH  - Bone Marrow/pathology
MH  - Child
MH  - *Chromosome Aberrations
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 7
MH  - *Chromosomes, Human, Pair 8
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukopenia
MH  - Myelodysplastic Syndromes/*genetics/pathology
MH  - Trisomy
EDAT- 1999/02/12 00:00
MHDA- 1999/02/12 00:01
CRDT- 1999/02/12 00:00
PHST- 1999/02/12 00:00 [pubmed]
PHST- 1999/02/12 00:01 [medline]
PHST- 1999/02/12 00:00 [entrez]
AID - S0165460898001277 [pii]
AID - 10.1016/s0165-4608(98)00127-7 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jan 1;108(1):13-8. doi: 
      10.1016/s0165-4608(98)00127-7.