PMID- 9973938
OWN - NLM
STAT- MEDLINE
DCOM- 19990223
LR  - 20211203
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 108
IP  - 2
DP  - 1999 Jan 15
TI  - Deletion of cell division cycle 2-like 1 gene locus on 1p36 in non-Hodgkin 
      lymphoma.
PG  - 120-6
AB  - Our laboratories have documented a significantly high occurrence of chromosome 
      1p36 rearrangements in non-Hodgkin lymphoma (NHL). The cell division cycle 2-like 
      1(CDC2L1) (also known as TP58 or PITSLRE) gene, a protein kinase implicated in 
      apoptotic signaling, is located at the very distal region of chromosome 1p36 and 
      is likely to be disrupted by structural rearrangements involving 1p36. To 
      determine the molecular consequences of the recurrent involvement of the 1p36 
      region, we examined metaphases containing 1p36 abnormalities from 31 specimens 
      derived from 26 patients for the possible deletion of CDC2L1 by fluorescence in 
      situ hybridization (FISH) using the TP58clk-1 DNA probe. Twenty-three cases 
      exhibited the loss of CDC2L1 from the abnormal chromosome 1. In 2 of 26 cases, 
      the gene locus was translocated to the partner chromosome, and in four specimens, 
      all derived from one case, CDC2L1 was not deleted. This pilot investigation 
      suggests that 1p36 rearrangements, and consequently the loss of the CDC2L1 gene 
      locus, is important in NHL. This work also opens avenues for further molecular 
      studies and prognostic correlations.
FAU - Dave, B J
AU  - Dave BJ
AD  - Munroe Meyer Institute for Genetics and Rehabilitation, University of Nebraska 
      Medical Center, Omaha 68198-5440, USA.
FAU - Pickering, D L
AU  - Pickering DL
FAU - Hess, M M
AU  - Hess MM
FAU - Weisenburger, D D
AU  - Weisenburger DD
FAU - Armitage, J O
AU  - Armitage JO
FAU - Sanger, W G
AU  - Sanger WG
LA  - eng
GR  - CA36727/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.- (Protein Kinases)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.22 (CDK11a protein, human)
RN  - EC 2.7.11.22 (Cyclin-Dependent Kinases)
SB  - IM
MH  - *Chromosomes, Human, Pair 1
MH  - Cyclin-Dependent Kinases
MH  - *Gene Deletion
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Lymphoma, Non-Hodgkin/*genetics
MH  - Protein Kinases/*genetics
MH  - Protein Serine-Threonine Kinases
EDAT- 1999/02/12 00:00
MHDA- 1999/02/12 00:01
CRDT- 1999/02/12 00:00
PHST- 1999/02/12 00:00 [pubmed]
PHST- 1999/02/12 00:01 [medline]
PHST- 1999/02/12 00:00 [entrez]
AID - S0165460898001381 [pii]
AID - 10.1016/s0165-4608(98)00138-1 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jan 15;108(2):120-6. doi: 
      10.1016/s0165-4608(98)00138-1.