PMID- 9973946
OWN - NLM
STAT- MEDLINE
DCOM- 19990223
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 108
IP  - 2
DP  - 1999 Jan 15
TI  - Amplification of BCR-ABL rearrangement in atypical Philadelphia chromosome: a new 
      variant detected by fluorescence in situ hybridization in one case of acute 
      lymphoblastic leukemia.
PG  - 158-61
AB  - We report on a 67-year-old woman with acute lymphoblastic leukemia (ALL) who was 
      supposed to have a variant Philadelphia (Ph) translocation identified by 
      conventional cytogenetic techniques. Fluorescence in situ hybridization (FISH) 
      analysis demonstrated the presence of an amplification of BCR-ABL rearrangement 
      at locus 22q11. This is the first observation, to our knowledge, of a duplicated 
      BCR-ABL chimeric gene within the derived chromosome 22 in ALL. Our observation 
      supports the possibility of detecting a variant Ph chromosome at the single-cell 
      level by FISH analysis.
FAU - Poulain, S
AU  - Poulain S
AD  - Departement d'Hematologie-Immunologie-Cytogenetique, Centre Hospitalier de 
      Valenciennes, France.
FAU - Daudignon, A
AU  - Daudignon A
FAU - Le Baron, F
AU  - Le Baron F
FAU - Bisiau, H
AU  - Bisiau H
FAU - Simon, M
AU  - Simon M
FAU - Duthilleul, P
AU  - Duthilleul P
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
SB  - IM
MH  - Aged
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Female
MH  - Fusion Proteins, bcr-abl/*genetics
MH  - *Gene Rearrangement
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Philadelphia Chromosome
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/drug therapy/*genetics
EDAT- 1999/02/12 00:00
MHDA- 1999/02/12 00:01
CRDT- 1999/02/12 00:00
PHST- 1999/02/12 00:00 [pubmed]
PHST- 1999/02/12 00:01 [medline]
PHST- 1999/02/12 00:00 [entrez]
AID - S016546089800082X [pii]
AID - 10.1016/s0165-4608(98)00082-x [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jan 15;108(2):158-61. doi: 
      10.1016/s0165-4608(98)00082-x.