PMID- 9973948
OWN - NLM
STAT- MEDLINE
DCOM- 19990223
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 108
IP  - 2
DP  - 1999 Jan 15
TI  - Increased karyotype precision using fluorescence in situ hybridization and 
      spectral karyotyping in patients with myeloid malignancies.
PG  - 166-70
AB  - We studied seven patients with various malignant hematologic disorders using 
      fluorescence in situ hybridization (FISH) and one of these patients with spectral 
      karyotyping (SKY). With appropriate probes, the t(8;21) and inv(16) were 
      confirmed in two patients and the karyotypic precision was increased in five 
      others using FISH and SKY. Two of three patients with 12p rearrangements had a 
      deletion of one TEL allele. Thus, these newer techniques are an important adjunct 
      to accurate chromosome analysis in malignancy.
FAU - Fleischman, E W
AU  - Fleischman EW
AD  - Cancer Research Center, Moscow, Russia.
FAU - Reshmi, S
AU  - Reshmi S
FAU - Sokova, O I
AU  - Sokova OI
FAU - Kirichenko, O P
AU  - Kirichenko OP
FAU - Konstantinova, L N
AU  - Konstantinova LN
FAU - Kulagina, O E
AU  - Kulagina OE
FAU - Frenkel, M A
AU  - Frenkel MA
FAU - Rowley, J D
AU  - Rowley JD
LA  - eng
GR  - CA 42557/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Chromosome Banding
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence/*standards
MH  - Karyotyping/*methods
MH  - Leukemia, Myeloid/*genetics
MH  - Male
MH  - Middle Aged
EDAT- 1999/02/12 00:00
MHDA- 1999/02/12 00:01
CRDT- 1999/02/12 00:00
PHST- 1999/02/12 00:00 [pubmed]
PHST- 1999/02/12 00:01 [medline]
PHST- 1999/02/12 00:00 [entrez]
AID - S016546089800137X [pii]
AID - 10.1016/s0165-4608(98)00137-x [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jan 15;108(2):166-70. doi: 
      10.1016/s0165-4608(98)00137-x.