PMID- 9973949
OWN - NLM
STAT- MEDLINE
DCOM- 19990223
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 108
IP  - 2
DP  - 1999 Jan 15
TI  - Simultaneous occurrence of chronic myelogenous leukemia and non-Hodgkin lymphoma 
      at diagnosis.
PG  - 171-4
AB  - We describe a case with the simultaneous occurrence of chronic myelogenous 
      leukemia (CML) and non-Hodgkin lymphoma (NHL). Peripheral blood (PB) and bone 
      marrow (BM) smears showed typical CML features. Lymph node biopsy exhibited a 
      large-cell NHL. The Philadelphia chromosome or its molecular counterpart, the 
      BCR-ABL gene fusion, by detecting with dual color-(DC) fluorescence in situ 
      hybridization (FISH), was detected reliably both in metaphase spreads from BM and 
      in interphase nuclei from BM and follow-up PB cells, but was not detected in the 
      lymph node cells. Clinical features and laboratory findings show this case having 
      a coexistence of CML and NHL.
FAU - Acar, H
AU  - Acar H
AD  - Department of Medical Genetics, Selcuk University, Konya, Turkey.
FAU - Ecirli, S
AU  - Ecirli S
FAU - Gundogan, F
AU  - Gundogan F
FAU - Bulay, O
AU  - Bulay O
FAU - Acar, A
AU  - Acar A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
RN  - 5J49Q6B70F (Vincristine)
RN  - 80168379AG (Doxorubicin)
RN  - 8N3DW7272P (Cyclophosphamide)
RN  - EC 2.7.10.2 (Fusion Proteins, bcr-abl)
RN  - VB0R961HZT (Prednisone)
RN  - CHOP protocol
SB  - IM
MH  - Adult
MH  - Antineoplastic Combined Chemotherapy Protocols/therapeutic use
MH  - Bone Marrow/pathology
MH  - Cyclophosphamide/administration & dosage
MH  - Doxorubicin/administration & dosage
MH  - Female
MH  - Fusion Proteins, bcr-abl/genetics
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Leukemia, Myelogenous, Chronic, BCR-ABL Positive/*complications/drug 
      therapy/genetics/pathology
MH  - Lymphoma, Non-Hodgkin/*complications/drug therapy/genetics/pathology
MH  - Prednisone/administration & dosage
MH  - Vincristine/administration & dosage
EDAT- 1999/02/12 00:00
MHDA- 1999/02/12 00:01
CRDT- 1999/02/12 00:00
PHST- 1999/02/12 00:00 [pubmed]
PHST- 1999/02/12 00:01 [medline]
PHST- 1999/02/12 00:00 [entrez]
AID - S0165460898001162 [pii]
AID - 10.1016/s0165-4608(98)00116-2 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Jan 15;108(2):171-4. doi: 
      10.1016/s0165-4608(98)00116-2.