PMID- 9973967
OWN - NLM
STAT- MEDLINE
DCOM- 19990225
LR  - 20190816
IS  - 0165-4608 (Print)
IS  - 0165-4608 (Linking)
VI  - 109
IP  - 1
DP  - 1999 Feb
TI  - Identification of a ring chromosome in a myxoid malignant fibrous histiocytoma 
      with chromosome microdissection and fluorescence in situ hybridization.
PG  - 81-5
AB  - We investigated the origin of a ring chromosome in a myxoid malignant fibrous 
      histiocytoma (MFH) by microdissection and fluorescence in situ hybridization 
      (FISH) analyses. Cytogenetically, only two ring chromosomes were observed; the 
      smaller ring was seen more frequently. The latter was microdissected, and the 
      material used for FISH. Hybridization of the microdissected labeled DNA to normal 
      metaphase cells revealed that the signal localized only to 20q. Three signals 
      were seen in the tumor cells using either the microdissected 20q probe or 
      chromosome 20 centromeric probe, indicating the involvement of both the long arm 
      and the centromere in the ring chromosome. The short arm of chromosome 20 did not 
      appear to be involved in the formation of the ring chromosome.
FAU - Meloni-Ehrig, A M
AU  - Meloni-Ehrig AM
AD  - Genzyme Genetics, Scottsdale, Arizona, USA.
FAU - Chen, Z
AU  - Chen Z
FAU - Guan, X Y
AU  - Guan XY
FAU - Notohamiprodjo, M
AU  - Notohamiprodjo M
FAU - Shepard, R R
AU  - Shepard RR
FAU - Spanier, S S
AU  - Spanier SS
FAU - Trent, J M
AU  - Trent JM
FAU - Sandberg, A A
AU  - Sandberg AA
LA  - eng
GR  - CA 41183/CA/NCI NIH HHS/United States
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Cancer Genet Cytogenet
JT  - Cancer genetics and cytogenetics
JID - 7909240
SB  - IM
MH  - Adult
MH  - Biopsy
MH  - Centromere/genetics
MH  - Chromosome Mapping
MH  - *Chromosomes, Human, Pair 20
MH  - Female
MH  - Histiocytoma, Benign Fibrous/*genetics/*pathology/surgery
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Karyotyping
MH  - *Ring Chromosomes
EDAT- 1999/02/12 00:00
MHDA- 1999/02/12 00:01
CRDT- 1999/02/12 00:00
PHST- 1999/02/12 00:00 [pubmed]
PHST- 1999/02/12 00:01 [medline]
PHST- 1999/02/12 00:00 [entrez]
AID - S0165460898001514 [pii]
AID - 10.1016/s0165-4608(98)00151-4 [doi]
PST - ppublish
SO  - Cancer Genet Cytogenet. 1999 Feb;109(1):81-5. doi: 10.1016/s0165-4608(98)00151-4.