PMID- 9986823
OWN - NLM
STAT- MEDLINE
DCOM- 19990316
LR  - 20200724
IS  - 0095-1137 (Print)
IS  - 1098-660X (Electronic)
IS  - 0095-1137 (Linking)
VI  - 37
IP  - 3
DP  - 1999 Mar
TI  - Mycoplasma hyopneumoniae potentiation of porcine reproductive and respiratory 
      syndrome virus-induced pneumonia.
PG  - 620-7
AB  - An experimental model that demonstrates a mycoplasma species acting to potentiate 
      a viral pneumonia was developed. Mycoplasma hyopneumoniae, which produces a 
      chronic, lymphohistiocytic bronchopneumonia in pigs, was found to potentiate the 
      severity and the duration of a virus-induced pneumonia in pigs. Pigs were 
      inoculated with M. hyopneumoniae 21 days prior to, simultaneously with, or 10 
      days after inoculation with porcine reproductive and respiratory syndrome virus 
      (PRRSV), which induces an acute interstitial pneumonia in pigs. PRRSV-induced 
      clinical respiratory disease and macroscopic and microscopic pneumonic lesions 
      were more severe and persistent in M. hyopneumoniae-infected pigs. At 28 or 38 
      days after PRRSV inoculation, M. hyopneumoniae-infected pigs still exhibited 
      lesions typical of PRRSV-induced pneumonia, whereas the lungs of pigs which had 
      received only PRRSV were essentially normal. On the basis of macroscopic lung 
      lesions, it appears that PRRSV infection did not influence the severity of M. 
      hyopneumoniae infection, although microscopic lesions typical of M. hyopneumoniae 
      were more severe in PRRSV-infected pigs. These results indicate that M. 
      hyopneumoniae infection potentiates PRRSV-induced disease and lesions. Most 
      importantly, M. hyopneumoniae-infected pigs with minimal to nondetectable 
      mycoplasmal pneumonia lesions manifested significantly increased PRRSV-induced 
      pneumonia lesions compared to pigs infected with PRRSV only. This discovery is 
      important with respect to the control of respiratory disease in pigs and has 
      implications in elucidating the potential contribution of mycoplasmas in the 
      pathogenesis of viral infections of other species, including humans.
FAU - Thacker, E L
AU  - Thacker EL
AD  - Veterinary Medical Research Institute, College of Veterinary Medicine, Iowa State 
      University, Ames, Iowa 50011, USA. ethacker@iastate.edu
FAU - Halbur, P G
AU  - Halbur PG
FAU - Ross, R F
AU  - Ross RF
FAU - Thanawongnuwech, R
AU  - Thanawongnuwech R
FAU - Thacker, B J
AU  - Thacker BJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Clin Microbiol
JT  - Journal of clinical microbiology
JID - 7505564
SB  - IM
MH  - Animals
MH  - Lung/microbiology/*pathology/virology
MH  - Mycoplasma/isolation & purification
MH  - Mycoplasma Infections/complications/pathology/*veterinary
MH  - Pneumonia, Bacterial/complications/pathology/*veterinary
MH  - Pneumonia, Viral/complications/pathology/*veterinary
MH  - Porcine Reproductive and Respiratory 
      Syndrome/microbiology/pathology/*physiopathology
MH  - Porcine respiratory and reproductive syndrome virus/isolation & purification
MH  - Swine
MH  - Swine Diseases/*microbiology/pathology
PMC - PMC84495
EDAT- 1999/02/13 00:00
MHDA- 1999/02/13 00:01
PMCR- 1999/03/01
CRDT- 1999/02/13 00:00
PHST- 1999/02/13 00:00 [pubmed]
PHST- 1999/02/13 00:01 [medline]
PHST- 1999/02/13 00:00 [entrez]
PHST- 1999/03/01 00:00 [pmc-release]
AID - 0962 [pii]
AID - 10.1128/JCM.37.3.620-627.1999 [doi]
PST - ppublish
SO  - J Clin Microbiol. 1999 Mar;37(3):620-7. doi: 10.1128/JCM.37.3.620-627.1999.