PMID- 9987571
OWN - NLM
STAT- MEDLINE
DCOM- 19990430
LR  - 20200923
IS  - 0390-6663 (Print)
IS  - 0390-6663 (Linking)
VI  - 25
IP  - 4
DP  - 1998
TI  - Biochemical markers of n-3 long chain polyunsaturated fatty acid intake during 
      pregnancy.
PG  - 135-8
AB  - BACKGROUND: To assess the relationship between the mothers' intake of n-3 long 
      chain polyunsaturated fatty acids (LC PUFA) during pregnancy and their levels in 
      plasma and tissue. METHODS: 162 mothers were studied during labor. Three groups 
      were differentiated according to the n3 LC PUFA intake assessed by means of a 
      dietetic interview: superior intake (SIG) (> 0.721 g/day), medium intake (MIG) 
      (from 0.382 to 0.721 g/day) and inferior intake (IIG) (< 0.381 g/day). Fatty 
      acids (FA) were studied by capillary chromatography in plasma and in erythrocyte 
      phospholipids. RESULTS: The fatty acids (FA), expressed in absolute values, did 
      not show any significant differences among the aforementioned groups. However, 
      three were some trends which were confirmed when the FA were expressed in 
      percentages. Thus, higher levels of docosahexaenoic acid (DHA) were found in SIG 
      both in plasma and in the erythrocyte membrane, when expressed in percentages. 
      Eicosapentaenoic acid (EPA) was also higher in the SIG in the erythrocyte 
      membrane, whereas in plasma the differences were of marginal significance. On the 
      other hand, arachidonic and linoleic acids had lower values in the SIG in 
      erythrocytes. The theoretical optimal intake of n-3 LC PUFA corresponded to a 
      plasma concentration of 117.9 +/- 45.9 mcg/ml n-3 LC PUFA or 2.54% of the total 
      fatty content (2.29% of DHA). The corresponding cut-offs in erythrocyte membranes 
      were 7.54% of total lipids (5.59% of DHA). CONCLUSION: The best markers of n-3 LC 
      PUFA intake were DHA for plasma and DHA and EPA for erythrocyte phospholipids, 
      all of them expressed in proportions of total FA. The arachidonic and linoleic 
      acids (in percentages) in erythrocyte phospholipids were also good markers of n-3 
      intake. This probably reflects the metabolic competition between both PUFA 
      families.
FAU - Matorras, R
AU  - Matorras R
AD  - Department of Obstetrics and Gynecology, Hospital from Cruces Pais Vasco 
      University, Baracaldo, Vizcaya, Spain.
FAU - Perteagudo, L
AU  - Perteagudo L
FAU - Sanjurjo, P
AU  - Sanjurjo P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Singapore
TA  - Clin Exp Obstet Gynecol
JT  - Clinical and experimental obstetrics & gynecology
JID - 7802110
RN  - 0 (Biomarkers)
RN  - 0 (Eicosanoic Acids)
RN  - 0 (Fatty Acids, Omega-3)
RN  - 25167-62-8 (Docosahexaenoic Acids)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - *Diet
MH  - Docosahexaenoic Acids/*blood
MH  - Eicosanoic Acids/*blood
MH  - Erythrocyte Membrane/chemistry
MH  - Fatty Acids, Omega-3/*administration & dosage/blood/pharmacokinetics
MH  - Female
MH  - Humans
MH  - Nutrition Policy
MH  - Pregnancy/blood/*metabolism
EDAT- 1999/02/13 00:00
MHDA- 1999/02/13 00:01
CRDT- 1999/02/13 00:00
PHST- 1999/02/13 00:00 [pubmed]
PHST- 1999/02/13 00:01 [medline]
PHST- 1999/02/13 00:00 [entrez]
PST - ppublish
SO  - Clin Exp Obstet Gynecol. 1998;25(4):135-8.