PMID- 9987627
OWN - NLM
STAT- MEDLINE
DCOM- 19990325
LR  - 20190905
IS  - 0721-832X (Print)
IS  - 0721-832X (Linking)
VI  - 237
IP  - 2
DP  - 1999 Feb
TI  - Quantification of blood-aqueous barrier breakdown after photorefractive 
      keratectomy for myopia.
PG  - 113-6
AB  - BACKGROUND: Photorefractive keratectomy (PRK) using the excimer laser is a 
      well-established surgical technique for correction of mild to moderate myopic 
      refraction errors in case of spectacle or contact lens incompatibility. As it is 
      still uncertain whether this procedure causes intraocular inflammatory changes, 
      it was the purpose of this study to quantify breakdown of the blood-aqueous 
      barrier following PRK and to look for possible correlations with clinical 
      parameters. PATIENTS AND METHODS: Aqueous flare was quantified using the laser 
      flare-cell meter after medical pupil dilation preoperatively and on days 1, 3 and 
      7 as well as 1 month and 3 months following PRK with a 193-nm excimer laser (MEL 
      60, Aesculap-Meditec) in 37 eyes of 22 patients. The preoperative spherical 
      equivalents were -4.4 +/- 3.1 D (range -1.5 to -8.0 D). Pre-, intra- and 
      postoperative treatment was standardized. RESULTS: Preoperatively, aqueous flare 
      values were 3.9 +/- 0.8 photon counts/ms and showed no significant correlation 
      with the spherical equivalent (p > 0.1). Postoperatively, aqueous flare rise was 
      very small with flare values not significantly higher than preoperative values. 
      All postoperative flare values were below the normal limit (< 8.0 photon 
      counts/ms). Flare was highest on day 3 after PRK surgery. There was no 
      statistically significant correlation between aqueous flare and depth of stromal 
      ablation. The number of aqueous "cells" did not increase following PRK at any 
      postoperative follow-up examination. CONCLUSION: Our results indicate that PRK in 
      mild to moderate myopia does not cause a significant breakdown of the 
      blood-aqueous barrier.
FAU - Nguyen, N X
AU  - Nguyen NX
AD  - Augenklinik mit Poliklinik, Universitat Erlangen-Nurnberg, Germany. 
      nhung.nguyen@augen.med.uni-erlangen.de
FAU - Seitz, B
AU  - Seitz B
FAU - Langenbucher, A
AU  - Langenbucher A
FAU - Kuchle, M
AU  - Kuchle M
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Graefes Arch Clin Exp Ophthalmol
JT  - Graefe's archive for clinical and experimental ophthalmology = Albrecht von 
      Graefes Archiv fur klinische und experimentelle Ophthalmologie
JID - 8205248
SB  - IM
MH  - Adult
MH  - Anterior Eye Segment/*blood supply
MH  - Aqueous Humor/cytology/*metabolism
MH  - *Blood-Aqueous Barrier
MH  - Capillary Permeability
MH  - Cornea/*surgery
MH  - Diagnostic Techniques, Ophthalmological/instrumentation
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lasers
MH  - Lasers, Excimer
MH  - Male
MH  - Middle Aged
MH  - Myopia/*surgery
MH  - *Photorefractive Keratectomy
EDAT- 1999/02/13 00:00
MHDA- 1999/02/13 00:01
CRDT- 1999/02/13 00:00
PHST- 1999/02/13 00:00 [pubmed]
PHST- 1999/02/13 00:01 [medline]
PHST- 1999/02/13 00:00 [entrez]
AID - 10.1007/s004170050205 [doi]
PST - ppublish
SO  - Graefes Arch Clin Exp Ophthalmol. 1999 Feb;237(2):113-6. doi: 
      10.1007/s004170050205.