PMID- 9987758
OWN - NLM
STAT- MEDLINE
DCOM- 19990415
LR  - 20170214
IS  - 1352-4585 (Print)
IS  - 1352-4585 (Linking)
VI  - 4
IP  - 6
DP  - 1998 Dec
TI  - Human Herpesvirus-6 (HHV-6) infection in multiple sclerosis: a preliminary 
      report.
PG  - 490-6
AB  - We examined cerebral spinal fluid (CSF) from multiple sclerosis (MS) patients and 
      patients with other neurological diseases (OND) for antibody specific for Human 
      Herpesvirus-6 (HHV-6) and for HHV-6 DNA detectable by PCR. CSF from MS patients 
      had a higher frequency of IgG antibody to HHV-6 late antigens (39.4%) compared 
      with CSF from OND (7.4%). In contrast, the frequency of detectable IgG antibody 
      in CSF from MS patients specific for Epstein-Barr Virus (EBV) (12.1%) and Human 
      Cytomegalovirus (HCMV) (6.1%) was much lower. Two of 12 MS CSFs (16.7%) also 
      contained HHV-6 DNA detected by PCR. None of four OND CSF were positive for HHV-6 
      DNA. Plasma from 16 patients with MS, eight with OND and 72 healthy donors were 
      tested for antibodies by ELISA to HHV-6 early (p41/38) and late (gp110) proteins. 
      Although no differences in anti-gp110 IgG antibody were detected between MS 
      patients, patients with other neurological diseases, and normals, IgG antibody to 
      early protein p41/38 was detected in > 68% of the plasma from MS patients, 12.5% 
      from OND patients and 27.8% of the controls. IgM antibody to p41/38 was present 
      in > 56% of MS patients, 12.5% of OND patients, and 19% of controls. These data 
      suggest that more than half of the MS patients had active, ongoing HHV-6 
      infections. HHV-6 was also isolated from peripheral blood mononuclear cells 
      (PBMC) from 3/5 MS patients who were in relapse or had progressive disease and 
      was identified as HHV-6 Variant B. These preliminary results support the 
      hypothesis that HHV-6 may be a co-factor in the pathogenesis of some cases of MS.
FAU - Ablashi, D V
AU  - Ablashi DV
AD  - Advanced Biotechnologies Inc, Columbia, Maryland 21046, USA.
FAU - Lapps, W
AU  - Lapps W
FAU - Kaplan, M
AU  - Kaplan M
FAU - Whitman, J E
AU  - Whitman JE
FAU - Richert, J R
AU  - Richert JR
FAU - Pearson, G R
AU  - Pearson GR
LA  - eng
PT  - Journal Article
PL  - England
TA  - Mult Scler
JT  - Multiple sclerosis (Houndmills, Basingstoke, England)
JID - 9509185
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
SB  - IM
MH  - Antibodies, Viral/cerebrospinal fluid
MH  - Cells, Cultured
MH  - Cerebrospinal Fluid/virology
MH  - DNA, Viral/blood/cerebrospinal fluid
MH  - Herpesviridae Infections/*complications
MH  - *Herpesvirus 6, Human/genetics/immunology/isolation & purification
MH  - Humans
MH  - Microscopy, Electron
MH  - Monocytes/ultrastructure/virology
MH  - Multiple Sclerosis/blood/cerebrospinal fluid/*virology
MH  - Nervous System Diseases/blood/cerebrospinal fluid
EDAT- 1999/02/13 00:00
MHDA- 1999/02/13 00:01
CRDT- 1999/02/13 00:00
PHST- 1999/02/13 00:00 [pubmed]
PHST- 1999/02/13 00:01 [medline]
PHST- 1999/02/13 00:00 [entrez]
AID - 10.1177/135245859800400606 [doi]
PST - ppublish
SO  - Mult Scler. 1998 Dec;4(6):490-6. doi: 10.1177/135245859800400606.