PMID- 9987919
OWN - NLM
STAT- MEDLINE
DCOM- 19990318
LR  - 20190513
IS  - 0022-1503 (Print)
IS  - 0022-1503 (Linking)
VI  - 90
IP  - 1
DP  - 1999 Jan-Feb
TI  - Genetic studies in narcolepsy, a disorder affecting REM sleep.
PG  - 129-32
AB  - Narcolepsy is a disabling sleep disorder characterized by excessive daytime 
      sleepiness and abnormal manifestations of rapid eye movement (REM) sleep 
      including cataplexy, sleep paralysis, and hypnagogic hallucinations. It is known 
      to be a complex disorder, with both genetic predisposition and environmental 
      factors playing a role. In humans, susceptibility to narcolepsy is tightly 
      associated with a specific HLA allele, DQB1*0602. In humans and canines, most 
      cases are sporadic. In Doberman pinschers and Labrador retrievers, however, the 
      disease is transmitted as an autosomal recessive gene canarc-1 with full 
      penetrance. This gene is not linked with the dog leukocyte antigen complex, but 
      is tightly linked with a marker with high homology to the human mu-switch 
      immunoglobulin gene. We have isolated several genomic clones encompassing the 
      canarc-1 marker and the variable heavy chain immunoglobulin region in canines. 
      These have been partially sequenced and have been mapped onto specific dog 
      chromosomes by fluorescence in situ hybridization (FISH). Our results indicate 
      that the mu-switch-like marker is not part of the canine immunoglobulin 
      machinery. We are continuing to extend the genomic contig using a newly developed 
      canine BAC library and attempting to identify the corresponding human region of 
      conserved synteny.
FAU - Faraco, J
AU  - Faraco J
AD  - Department of Psychiatry and Behavioral Sciences, Stanford University School of 
      Medicine, California, USA.
FAU - Lin, X
AU  - Lin X
FAU - Li, R
AU  - Li R
FAU - Hinton, L
AU  - Hinton L
FAU - Lin, L
AU  - Lin L
FAU - Mignot, E
AU  - Mignot E
LA  - eng
GR  - NS23724/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Hered
JT  - The Journal of heredity
JID - 0375373
RN  - 0 (Genetic Markers)
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Animals
MH  - Dog Diseases/*genetics
MH  - Dogs
MH  - Genetic Markers
MH  - HLA Antigens/genetics
MH  - Humans
MH  - Narcolepsy/genetics/*veterinary
MH  - *Sleep, REM
RF  - 34
EDAT- 1999/02/13 00:00
MHDA- 1999/02/13 00:01
CRDT- 1999/02/13 00:00
PHST- 1999/02/13 00:00 [pubmed]
PHST- 1999/02/13 00:01 [medline]
PHST- 1999/02/13 00:00 [entrez]
AID - 10.1093/jhered/90.1.129 [doi]
PST - ppublish
SO  - J Hered. 1999 Jan-Feb;90(1):129-32. doi: 10.1093/jhered/90.1.129.