PMID- 9988231
OWN - NLM
STAT- MEDLINE
DCOM- 19990223
LR  - 20190708
IS  - 0020-7136 (Print)
IS  - 0020-7136 (Linking)
VI  - 84
IP  - 1
DP  - 1999 Feb 19
TI  - High levels of tissue inhibitor of metalloproteinase-1 predict poor outcome in 
      patients with breast cancer.
PG  - 44-8
AB  - Studies from model systems suggest that matrix metalloproteinases (MMPs) are 
      causally involved in tumor progression while tissue inhibitors of MMPs (TIMPs) 
      prevent this progression. Here, we show that concentrations of TIMP-1 are 
      significantly higher in breast carcinomas than in fibroadenomas. In primary 
      breast cancers, TIMP-1 concentrations increased with increasing tumor size but 
      showed an inverse relationship with estrogen receptor concentrations. In primary 
      breast cancers also, TIMP-1 levels were weakly but significantly correlated with 
      those for MMP-1, proMMP-2, active MMP-2, MMP-3 and proMMP-9. Contrary to what 
      might be expected from published data on model systems, high concentrations of 
      TIMP-1 predicted a poor outcome in patients with breast cancer. We conclude that 
      in human breast cancer, endogenous TIMP-1 does not inhibit tumor progression but 
      may enhance the process.
FAU - McCarthy, K
AU  - McCarthy K
AD  - Department of Nuclear Medicine, St. Vincent's Hospital, Dublin, Ireland.
FAU - Maguire, T
AU  - Maguire T
FAU - McGreal, G
AU  - McGreal G
FAU - McDermott, E
AU  - McDermott E
FAU - O'Higgins, N
AU  - O'Higgins N
FAU - Duffy, M J
AU  - Duffy MJ
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Int J Cancer
JT  - International journal of cancer
JID - 0042124
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Tissue Inhibitor of Metalloproteinase-1)
RN  - EC 3.4.24.- (Collagenases)
RN  - EC 3.4.24.- (Gelatinases)
RN  - EC 3.4.24.- (Metalloendopeptidases)
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
RN  - EC 3.4.24.24 (Matrix Metalloproteinase 2)
RN  - EC 3.4.24.7 (Matrix Metalloproteinase 1)
SB  - IM
MH  - Biomarkers, Tumor/*analysis
MH  - Breast Neoplasms/*metabolism/mortality
MH  - Collagenases/analysis/metabolism
MH  - Disease Progression
MH  - Female
MH  - Gelatinases/analysis
MH  - Humans
MH  - Matrix Metalloproteinase 1
MH  - Matrix Metalloproteinase 2
MH  - Matrix Metalloproteinase 3/analysis
MH  - Metalloendopeptidases/analysis
MH  - Prognosis
MH  - Survival Rate
MH  - Tissue Inhibitor of Metalloproteinase-1/*analysis
EDAT- 1999/02/13 03:14
MHDA- 2000/06/20 09:00
CRDT- 1999/02/13 03:14
PHST- 1999/02/13 03:14 [pubmed]
PHST- 2000/06/20 09:00 [medline]
PHST- 1999/02/13 03:14 [entrez]
AID - 10.1002/(SICI)1097-0215(19990219)84:1<44::AID-IJC9>3.0.CO;2-P [pii]
AID - 10.1002/(sici)1097-0215(19990219)84:1<44::aid-ijc9>3.0.co;2-p [doi]
PST - ppublish
SO  - Int J Cancer. 1999 Feb 19;84(1):44-8. doi: 
      10.1002/(sici)1097-0215(19990219)84:1<44::aid-ijc9>3.0.co;2-p.