PMID- 9988837
OWN - NLM
STAT- MEDLINE
DCOM- 19990527
LR  - 20190915
IS  - 0920-9964 (Print)
IS  - 0920-9964 (Linking)
VI  - 35
IP  - 1
DP  - 1999 Jan 4
TI  - Negative symptoms of familial schizophrenia breed true in unstable (vs. stable) 
      cerebral-ventricle pedigrees.
PG  - 15-23
AB  - A pattern of negative symptoms associated with a high rate of ongoing brain and 
      ventricular instability has been described in a cohort of schizophrenia spectrum 
      probands (patients with schizophrenia, schizoaffective disorder depressed and 
      bipolar, and psychosis NOS) (Garver, D.L., Nair, T.R., Christensen, J.D., 
      Holcomb, J., Ramberg, J., Kingsbury, S., 1999. Differential patterns of premorbid 
      functioning, symptoms and neuroleptic response in stable and unstable 
      ventricular-volume schizophrenia. Neuropsychopharmacology 20, in press). The 
      present study contrasts the prevalence of negative symptoms in first- and 
      second-degree relatives of probands with unstable ventricle volume (UnsVV) and 
      stable ventricle volume (SVV). One hundred and sixteen first- and second-degree 
      relatives of 10 probands were interviewed using the SANS, the 'Characterization 
      of Course: "Pattern of Symptoms"' [from Comprehensive Assessment of Symptoms and 
      History (CASH)], SCID and SCID-II by interviewers blind to the status of the 
      proband. Thirty-five of the 116 family members met DSM-IV criteria for 
      schizophrenia, SA depressed, 'Cluster A' of the SCID-II (paranoid, schizotypal, 
      schizoid personality disorder), psychosis NOS, or psychotic affective disorder. 
      These 35 family members were defined as falling within a 'schizophrenia spectrum' 
      as described by Farmer, A.E., McGuffin, P., Gottesman, I.I., 1987. Arch. Gen. 
      Psychiatry 44, 634-641, but with the addition of DSM-IV affective psychosis. On 
      that basis, the 35 members were considered 'affected family members' (AFMs). The 
      remaining 81 family members were considered unaffected. The 'predominant symptoms 
      of illness' (during the past 2-3 years) for 25 of the 35 AFMs could be 
      characterized according to the 'Patterns of Symptoms' derived from the CASH. 
      Twenty-five of the 35 AFMs were found to maintain a predominant symptom pattern 
      during the course of illness, which could be characterized according to the 
      'Pattern of Symptoms' as 'predominantly positive' or 'predominantly negative'. 
      Three of the probands had UnsVV; seven had SVV. Of the 35 AFMs, 11 were related 
      to the UnsVV probands, and 24 were relatives of the SVV probands. The nine rated 
      AFMs of the UnsVV probands showed a trend toward higher SANS scores (7.3 +/- 5.1) 
      (mean +/- s.d.) than the 20 rated AFMs of SVV probands (4.3 +/- 5.1) (p = 0.08) 
      at the time of the interview. Eighty-three per cent (eight of 10) of rated 
      affected pedigree members of the pedigrees delineated by probands with UnsVV 
      probands had a predominantly negative symptom course of illness, and 96% (23 of 
      24) of rated affected pedigree members of the pedigrees with SVV probands had a 
      predominantly positive symptom course of illness during the preceding 2-3 years 
      (p = 0.002). None of the 12 rated affected pedigree members within pedigrees 
      having UnsVV probands were married at the time of the interview; 45% (14 of 31) 
      of affected pedigree members having SVV probands were married (p = 0.004). A 
      psychiatric disorder, characterized by unstable cerebral ventricles and 
      predominant negative symptoms (including avoidance/failure of marital 
      relationships) appears symptomatically to breed true in pedigrees containing 
      schizophrenia-like illnesses.
FAU - Filbey, F M
AU  - Filbey FM
AD  - Dallas VAMC, TX, USA.
FAU - Holcomb, J
AU  - Holcomb J
FAU - Nair, T R
AU  - Nair TR
FAU - Christensen, J D
AU  - Christensen JD
FAU - Garver, D L
AU  - Garver DL
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cerebral Ventricles/*abnormalities
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Pedigree
MH  - Psychiatric Status Rating Scales
MH  - Psychotic Disorders/etiology
MH  - Schizophrenia/diagnosis/*genetics
MH  - Schizophrenic Psychology
EDAT- 1999/02/16 00:00
MHDA- 1999/02/16 00:01
CRDT- 1999/02/16 00:00
PHST- 1999/02/16 00:00 [pubmed]
PHST- 1999/02/16 00:01 [medline]
PHST- 1999/02/16 00:00 [entrez]
AID - S0920-9964(98)00107-8 [pii]
AID - 10.1016/s0920-9964(98)00107-8 [doi]
PST - ppublish
SO  - Schizophr Res. 1999 Jan 4;35(1):15-23. doi: 10.1016/s0920-9964(98)00107-8.