PMID- 9989243
OWN - NLM
STAT- MEDLINE
DCOM- 19990225
LR  - 20190610
IS  - 0006-3002 (Print)
IS  - 0006-3002 (Linking)
VI  - 1453
IP  - 1
DP  - 1999 Jan 6
TI  - Enhanced tumor necrosis factor-alpha production following endotoxin challenge in 
      rats is an early event during magnesium deficiency.
PG  - 35-40
AB  - Magnesium (Mg) plays an essential role in fundamental cellular reactions and the 
      importance of the immuno-inflammatory processes in the pathology of Mg deficiency 
      has been recently reconsidered. The purpose of the present study was to assess 
      the effect of different stages of Mg deficiency on endotoxin response and tumor 
      necrosis factor-alpha (TNF alpha) production. Weaning male Wistar rats were pair 
      fed either a Mg-deficient or a control diet. At day 7, lipopolysaccharide (LPS) 
      induced no lethal effects in control rats but resulted in 70% mortality in 
      Mg-deficient rats within 3 h. The vulnerability of Mg-deficient rats to LPS was 
      associated with higher TNF alpha plasma values. Mg-deficient animals that 
      received magnesium supplementation before endotoxin challenge had significantly 
      increased survival. At day 2, control and Mg-deficient rats were also subjected 
      to endotoxin challenge with or without magnesium pre-treatment. A significant 
      increase in TNF alpha plasma level was observed in Mg-deficient rats compared to 
      rats fed the control diet. Mg-deficient rats that received magnesium replacement 
      therapy before endotoxin challenge had significantly lower TNF alpha plasma 
      values than those receiving saline before endotoxin. Thus, the results of this 
      experiment suggest that the activated or primed state of immune cells is an early 
      event occurring in Mg deficiency.
FAU - Malpuech-Brugere, C
AU  - Malpuech-Brugere C
AD  - Centre de Recherches en Nutrition Humaine, Unite Maladies Metaboliques et 
      Micronutriments-INRA-Theix, Saint-Genes-Champanelle, France.
FAU - Nowacki, W
AU  - Nowacki W
FAU - Rock, E
AU  - Rock E
FAU - Gueux, E
AU  - Gueux E
FAU - Mazur, A
AU  - Mazur A
FAU - Rayssiguier, Y
AU  - Rayssiguier Y
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Biochim Biophys Acta
JT  - Biochimica et biophysica acta
JID - 0217513
RN  - 0 (Endotoxins)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - I38ZP9992A (Magnesium)
SB  - IM
MH  - Animals
MH  - Endotoxins
MH  - Magnesium/blood/pharmacology
MH  - Magnesium Deficiency/blood/chemically induced/*metabolism
MH  - Male
MH  - Rats
MH  - Rats, Wistar
MH  - Tumor Necrosis Factor-alpha/analysis/*biosynthesis
EDAT- 1999/02/16 00:00
MHDA- 1999/02/16 00:01
CRDT- 1999/02/16 00:00
PHST- 1999/02/16 00:00 [pubmed]
PHST- 1999/02/16 00:01 [medline]
PHST- 1999/02/16 00:00 [entrez]
AID - S0925-4439(98)00081-7 [pii]
AID - 10.1016/s0925-4439(98)00081-7 [doi]
PST - ppublish
SO  - Biochim Biophys Acta. 1999 Jan 6;1453(1):35-40. doi: 
      10.1016/s0925-4439(98)00081-7.