PMID- 9989850
OWN - NLM
STAT- MEDLINE
DCOM- 19990224
LR  - 20190822
IS  - 0147-5185 (Print)
IS  - 0147-5185 (Linking)
VI  - 23
IP  - 2
DP  - 1999 Feb
TI  - Synovial sarcoma of the prostate with t(X;18)(p11.2;q11.2).
PG  - 220-6
AB  - A case of monophasic synovial sarcoma of the prostate in a 37-year-old man is 
      reported. Histologically, the tumor was chiefly composed of uniform spindle and 
      oval cells, which often formed interlacing fascicles resembling those of 
      fibrosarcoma. In some areas, the compact fascicles of tumor cells alternated with 
      hypocellular myxoid tissue bearing a superficial resemblance to peripheral nerve 
      sheath tumors, whereas small portions of the tumor showed a pericytomatous 
      pattern consisting of polygonal cells arranged around dilated, thin-walled blood 
      vessels. By immunohistochemistry, vimentin was detected in most cells, and a 
      focal reactivity for epithelial membrane antigen was also observed. The tumor 
      cells, however, were negative for keratin, S-100 protein, neuron-specific 
      enolase, CD34, desmin, muscle-specific actin, and alpha-smooth muscle actin. 
      Cytogenetic analysis and fluorescence in situ hybridization (FISH) using the 
      cultured tumor cells demonstrated a translocation t(X;18)(p11.2;q11.2), an 
      aberration specific for synovial sarcoma. To the authors' knowledge, this is the 
      first report of a primary prostatic synovial sarcoma confirmed by cytogenetic 
      analysis.
FAU - Iwasaki, H
AU  - Iwasaki H
AD  - Department of Pathology, Fukuoka University School of Medicine, Japan.
FAU - Ishiguro, M
AU  - Ishiguro M
FAU - Ohjimi, Y
AU  - Ohjimi Y
FAU - Ikegami, H
AU  - Ikegami H
FAU - Takeuchi, T
AU  - Takeuchi T
FAU - Kikuchi, M
AU  - Kikuchi M
FAU - Kaneko, Y
AU  - Kaneko Y
FAU - Ariyoshi, A
AU  - Ariyoshi A
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Am J Surg Pathol
JT  - The American journal of surgical pathology
JID - 7707904
RN  - 0 (Biomarkers, Tumor)
SB  - IM
MH  - Adult
MH  - Biomarkers, Tumor/analysis
MH  - Chromosomes, Human, Pair 18/*genetics
MH  - Humans
MH  - Immunoenzyme Techniques
MH  - Karyotyping
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Prostatic Neoplasms/chemistry/diagnosis/*genetics
MH  - Sarcoma, Synovial/chemistry/diagnostic imaging/*genetics/pathology
MH  - Tomography, X-Ray Computed
MH  - *Translocation, Genetic
MH  - X Chromosome/*genetics
EDAT- 1999/02/16 00:00
MHDA- 1999/02/16 00:01
CRDT- 1999/02/16 00:00
PHST- 1999/02/16 00:00 [pubmed]
PHST- 1999/02/16 00:01 [medline]
PHST- 1999/02/16 00:00 [entrez]
AID - 10.1097/00000478-199902000-00012 [doi]
PST - ppublish
SO  - Am J Surg Pathol. 1999 Feb;23(2):220-6. doi: 10.1097/00000478-199902000-00012.