PMID- 9990422
OWN - NLM
STAT- MEDLINE
DCOM- 19990225
LR  - 20191024
IS  - 0914-9465 (Print)
IS  - 0914-9465 (Linking)
VI  - 61
IP  - 5
DP  - 1998 Dec
TI  - Expression of macrophage colony-stimulating factor, scavenger receptors, and 
      macrophage proliferation in the pregnant mouse uterus.
PG  - 383-93
AB  - During pregnancy, mouse uterine epithelial cells produce and secrete a large 
      amount of macrophage colony-stimulating factor (M-CSF/CSF-1). Macrophages 
      accumulate and proliferate in the undecidualized endometrium of the pregnant 
      uterus. Observations showed that macrophages expressed scavenger receptor class A 
      (type I and type II) and class C (macrosialin). Scavenger receptors appeared to 
      be involved in the removal of apoptotic cells in the degenerated decidual tissue. 
      The expression of class A and class C scavenger receptor mRNAs in the uterus of 
      pregnant mice was elevated but the expression of class B scavenger receptor 
      (CD36) mRNA was similar to that of non-pregnant mice. The expression of various 
      cytokines and chemokines, including M-CSF, monocyte chemoattractant protein-1 
      (MCP-1) and macrophage inflammatory protein 1-alpha (MIP1-alpha), was enhanced in 
      the uterus of pregnant mice, suggesting that these molecules regulate macrophage 
      chemotaxis and immunological function in the uterus. These findings imply that 
      the pregnant uterus provides a microenvironment for the recruitment, 
      differentiation, and proliferation of macrophages and the regulation of scavenger 
      receptor and cytokine expression for a successful pregnancy.
FAU - Kyaw, Y
AU  - Kyaw Y
AD  - Second Department of Pathology, Niigata University School of Medicine, Japan. 
      2byori@med.niigata-u.ac.jp
FAU - Hasegawa, G
AU  - Hasegawa G
FAU - Takatsuka, H
AU  - Takatsuka H
FAU - Shimada-Hiratsuka, M
AU  - Shimada-Hiratsuka M
FAU - Umezu, H
AU  - Umezu H
FAU - Arakawa, M
AU  - Arakawa M
FAU - Naito, M
AU  - Naito M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Japan
TA  - Arch Histol Cytol
JT  - Archives of histology and cytology
JID - 8806082
RN  - 0 (CD36 Antigens)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Chemokine CCL3)
RN  - 0 (Chemokine CCL4)
RN  - 0 (Macrophage Inflammatory Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Immunologic)
RN  - 0 (Receptors, Lipoprotein)
RN  - 0 (Receptors, Scavenger)
RN  - 0 (Scarb1 protein, mouse)
RN  - 0 (Scavenger Receptors, Class A)
RN  - 0 (Scavenger Receptors, Class B)
RN  - 0 (Scavenger Receptors, Class C)
RN  - 81627-83-0 (Macrophage Colony-Stimulating Factor)
SB  - IM
MH  - Animals
MH  - Apoptosis
MH  - CD36 Antigens
MH  - *Cell Division
MH  - Chemokine CCL2/genetics
MH  - Chemokine CCL3
MH  - Chemokine CCL4
MH  - Endometrium/metabolism
MH  - Epithelial Cells/metabolism
MH  - Female
MH  - Immunohistochemistry
MH  - In Situ Hybridization
MH  - Macrophage Colony-Stimulating Factor/*genetics
MH  - Macrophage Inflammatory Proteins/genetics
MH  - Macrophages/*cytology
MH  - *Membrane Proteins
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Pregnancy
MH  - RNA, Messenger/metabolism
MH  - Receptors, Immunologic/*genetics
MH  - *Receptors, Lipoprotein
MH  - Receptors, Scavenger
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Scavenger Receptors, Class A
MH  - Scavenger Receptors, Class B
MH  - Scavenger Receptors, Class C
MH  - Uterus/cytology/*metabolism
EDAT- 1999/02/17 00:00
MHDA- 1999/02/17 00:01
CRDT- 1999/02/17 00:00
PHST- 1999/02/17 00:00 [pubmed]
PHST- 1999/02/17 00:01 [medline]
PHST- 1999/02/17 00:00 [entrez]
AID - 10.1679/aohc.61.383 [doi]
PST - ppublish
SO  - Arch Histol Cytol. 1998 Dec;61(5):383-93. doi: 10.1679/aohc.61.383.