LOCUS NP_032412 108 aa linear ROD 11-MAR-2025
DEFINITION insulin-1 preproprotein [Mus musculus].
ACCESSION NP_032412
VERSION NP_032412.3
DBSOURCE REFSEQ: accession NM_008386.4
KEYWORDS RefSeq; RefSeq Select.
SOURCE Mus musculus (house mouse)
ORGANISM Mus musculus
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE 1 (residues 1 to 108)
AUTHORS Scavuzzo,M.A., Szlachcic,W.J., Hill,M.C., Ziojla,N.M., Teaw,J.,
Carlson,J.C., Tiessen,J., Chmielowiec,J., Martin,J.F. and
Borowiak,M.
TITLE Pancreatic organogenesis mapped through space and time
JOURNAL Exp Mol Med 57 (1), 204-220 (2025)
PUBMED 39779976
REFERENCE 2 (residues 1 to 108)
AUTHORS Austin,M.C., Muralidharan,C., Roy,S., Crowder,J.J., Piganelli,J.D.
and Linnemann,A.K.
TITLE Dysfunctional beta-cell autophagy induces beta-cell stress and
enhances islet immunogenicity
JOURNAL Front Immunol 16, 1504583 (2025)
PUBMED 39944686
REMARK Publication Status: Online-Only
REFERENCE 3 (residues 1 to 108)
AUTHORS Lin,H.H., Yu,I.S., Cheng,M.S., Chang,T.J., Lin,H.Y., Chang,Y.C.,
Ko,C.J., Chen,P.H., Lin,S.W., Huang,T.C., Huang,S.Y., Chen,T.Y.,
Kan,K.W., Huang,H.P. and Lee,M.S.
TITLE Spint1 disruption in mouse pancreas leads to glucose intolerance
and impaired insulin production involving HEPSIN/MAFA
JOURNAL Nat Commun 15 (1), 10537 (2024)
PUBMED 39627229
REMARK Publication Status: Online-Only
REFERENCE 4 (residues 1 to 108)
AUTHORS Kitamura,R.A., Hummel,D., Ustione,A., Piston,D.W. and Urano,F.
TITLE Dual role of neuroplastin in pancreatic beta cells: Regulating
insulin secretion and promoting islet inflammation
JOURNAL Proc Natl Acad Sci U S A 121 (33), e2411234121 (2024)
PUBMED 39666939
REFERENCE 5 (residues 1 to 108)
AUTHORS Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F.
TITLE A linkage map of mouse chromosome 19: definition of comparative
mapping relationships with human chromosomes 10 and 11 including
the MEN1 locus
JOURNAL Genomics 14 (1), 26-31 (1992)
PUBMED 1358795
REFERENCE 6 (residues 1 to 108)
AUTHORS Gittes,G.K. and Rutter,W.J.
TITLE Onset of cell-specific gene expression in the developing mouse
pancreas
JOURNAL Proc Natl Acad Sci U S A 89 (3), 1128-1132 (1992)
PUBMED 1371010
REFERENCE 7 (residues 1 to 108)
AUTHORS Mori,M., Ishizaki,K., Serikawa,T. and Yamada,J.
TITLE Localization of the rat insulin I gene (INS1) to chromosome 1q55 by
fluorescence in situ hybridization
JOURNAL Cytogenet Cell Genet 59 (1), 31-33 (1992)
PUBMED 1346376
REFERENCE 8 (residues 1 to 108)
AUTHORS Sawa,T., Ohgaku,S., Morioka,H. and Yano,S.
TITLE Molecular cloning and DNA sequence analysis of preproinsulin genes
in the NON mouse, an animal model of human non-obese,
non-insulin-dependent diabetes mellitus
JOURNAL J Mol Endocrinol 5 (1), 61-67 (1990)
PUBMED 2397023
REFERENCE 9 (residues 1 to 108)
AUTHORS Wentworth,B.M., Schaefer,I.M., Villa-Komaroff,L. and Chirgwin,J.M.
TITLE Characterization of the two nonallelic genes encoding mouse
preproinsulin
JOURNAL J Mol Evol 23 (4), 305-312 (1986)
PUBMED 3104603
REFERENCE 10 (residues 1 to 108)
AUTHORS Bunzli,H.F., Glatthaar,B., Kunz,P., Mulhaupt,E. and Humbel,R.E.
TITLE Amino acid sequence of the two insulins from mouse (Maus musculus)
JOURNAL Hoppe Seylers Z Physiol Chem 353 (3), 451-458 (1972)
PUBMED 5063718
COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The
reference sequence was derived from AC163452.12, BP773571.1,
AK008358.1 and BQ126282.1.
On Nov 8, 2006 this sequence version replaced NP_032412.2.
Summary: This gene encodes insulin, a peptide hormone that plays a
vital role in the regulation of carbohydrate and lipid metabolism.
The encoded precursor protein undergoes proteolytic cleavage to
produce a disulfide-linked heterodimeric functional protein that is
stored in secretory granules. An increase in blood glucose levels,
among others, induces the release of insulin from the secretory
granules. Mice deficient in the functional hormone encoded by this
gene develop diabetes mellitus. [provided by RefSeq, Aug 2015].
Publication Note: This RefSeq record includes a subset of the
publications that are available for this gene. Please see the Gene
record to access additional publications.
##Evidence-Data-START##
Transcript exon combination :: BP773571.1, BQ287625.1 [ECO:0000332]
RNAseq introns :: single sample supports all introns
SAMN00849374, SAMN00849377
[ECO:0000348]
##Evidence-Data-END##
##RefSeq-Attributes-START##
RefSeq Select criteria :: based on single protein-coding transcript
##RefSeq-Attributes-END##
FEATURES Location/Qualifiers
source 1..108
/organism="Mus musculus"
/strain="C57BL/6"
/db_xref="taxon:10090"
/chromosome="19"
/map="19 46.76 cM"
Protein 1..108
/product="insulin-1 preproprotein"
/note="insulin-1"
/calculated_mol_wt=9492
sig_peptide 1..24
/note="/evidence=ECO:0000269|PubMed:5063718; propagated
from UniProtKB/Swiss-Prot (P01325.1)"
/calculated_mol_wt=2686
proprotein 24..108
/product="insulin-1 proprotein"
/experiment="experimental evidence[PMID: 5063718]"
/calculated_mol_wt=9563
mat_peptide 25..54
/product="Insulin-1 B chain. /id=PRO_0000015842"
/note="propagated from UniProtKB/Swiss-Prot (P01325.1)"
/calculated_mol_wt=3440
Region 26..108
/region_name="IlGF_insulin_like"
/note="IlGF_like family, insulin_like subgroup, specific
to vertebrates. Members include a number of peptides
including insulin and insulin-like growth factors I and
II, which play a variety of roles in controlling processes
such as metabolism, growth and...; cd04367"
/db_xref="CDD:239833"
Site order(32,35,37,106)
/site_type="active"
/note="putative receptor binding surface [active]"
/db_xref="CDD:239833"
mat_peptide 88..108
/product="Insulin-1 A chain. /id=PRO_0000015844"
/note="propagated from UniProtKB/Swiss-Prot (P01325.1)"
/calculated_mol_wt=2370
CDS 1..108
/gene="Ins1"
/gene_synonym="Ins-1; Ins2-rs1"
/coded_by="NM_008386.4:210..536"
/db_xref="CCDS:CCDS29898.1"
/db_xref="GeneID:16333"
/db_xref="MGI:MGI:96572"
ORIGIN
1 mallvhflpl lallalwepk ptqafvkqhl cgphlvealy lvcgergffy tpksrreved
61 pqveqlelgg spgdlqtlal evarqkrgiv dqcctsicsl yqlenycn
//