LOCUS NP_032412 108 aa linear ROD 11-MAR-2025 DEFINITION insulin-1 preproprotein [Mus musculus]. ACCESSION NP_032412 VERSION NP_032412.3 DBSOURCE REFSEQ: accession NM_008386.4 KEYWORDS RefSeq; RefSeq Select. SOURCE Mus musculus (house mouse) ORGANISM Mus musculus Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. REFERENCE 1 (residues 1 to 108) AUTHORS Scavuzzo,M.A., Szlachcic,W.J., Hill,M.C., Ziojla,N.M., Teaw,J., Carlson,J.C., Tiessen,J., Chmielowiec,J., Martin,J.F. and Borowiak,M. TITLE Pancreatic organogenesis mapped through space and time JOURNAL Exp Mol Med 57 (1), 204-220 (2025) PUBMED 39779976 REFERENCE 2 (residues 1 to 108) AUTHORS Austin,M.C., Muralidharan,C., Roy,S., Crowder,J.J., Piganelli,J.D. and Linnemann,A.K. TITLE Dysfunctional beta-cell autophagy induces beta-cell stress and enhances islet immunogenicity JOURNAL Front Immunol 16, 1504583 (2025) PUBMED 39944686 REMARK Publication Status: Online-Only REFERENCE 3 (residues 1 to 108) AUTHORS Lin,H.H., Yu,I.S., Cheng,M.S., Chang,T.J., Lin,H.Y., Chang,Y.C., Ko,C.J., Chen,P.H., Lin,S.W., Huang,T.C., Huang,S.Y., Chen,T.Y., Kan,K.W., Huang,H.P. and Lee,M.S. TITLE Spint1 disruption in mouse pancreas leads to glucose intolerance and impaired insulin production involving HEPSIN/MAFA JOURNAL Nat Commun 15 (1), 10537 (2024) PUBMED 39627229 REMARK Publication Status: Online-Only REFERENCE 4 (residues 1 to 108) AUTHORS Kitamura,R.A., Hummel,D., Ustione,A., Piston,D.W. and Urano,F. TITLE Dual role of neuroplastin in pancreatic beta cells: Regulating insulin secretion and promoting islet inflammation JOURNAL Proc Natl Acad Sci U S A 121 (33), e2411234121 (2024) PUBMED 39666939 REFERENCE 5 (residues 1 to 108) AUTHORS Rochelle,J.M., Watson,M.L., Oakey,R.J. and Seldin,M.F. TITLE A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus JOURNAL Genomics 14 (1), 26-31 (1992) PUBMED 1358795 REFERENCE 6 (residues 1 to 108) AUTHORS Gittes,G.K. and Rutter,W.J. TITLE Onset of cell-specific gene expression in the developing mouse pancreas JOURNAL Proc Natl Acad Sci U S A 89 (3), 1128-1132 (1992) PUBMED 1371010 REFERENCE 7 (residues 1 to 108) AUTHORS Mori,M., Ishizaki,K., Serikawa,T. and Yamada,J. TITLE Localization of the rat insulin I gene (INS1) to chromosome 1q55 by fluorescence in situ hybridization JOURNAL Cytogenet Cell Genet 59 (1), 31-33 (1992) PUBMED 1346376 REFERENCE 8 (residues 1 to 108) AUTHORS Sawa,T., Ohgaku,S., Morioka,H. and Yano,S. TITLE Molecular cloning and DNA sequence analysis of preproinsulin genes in the NON mouse, an animal model of human non-obese, non-insulin-dependent diabetes mellitus JOURNAL J Mol Endocrinol 5 (1), 61-67 (1990) PUBMED 2397023 REFERENCE 9 (residues 1 to 108) AUTHORS Wentworth,B.M., Schaefer,I.M., Villa-Komaroff,L. and Chirgwin,J.M. TITLE Characterization of the two nonallelic genes encoding mouse preproinsulin JOURNAL J Mol Evol 23 (4), 305-312 (1986) PUBMED 3104603 REFERENCE 10 (residues 1 to 108) AUTHORS Bunzli,H.F., Glatthaar,B., Kunz,P., Mulhaupt,E. and Humbel,R.E. TITLE Amino acid sequence of the two insulins from mouse (Maus musculus) JOURNAL Hoppe Seylers Z Physiol Chem 353 (3), 451-458 (1972) PUBMED 5063718 COMMENT REVIEWED REFSEQ: This record has been curated by NCBI staff. The reference sequence was derived from AC163452.12, BP773571.1, AK008358.1 and BQ126282.1. On Nov 8, 2006 this sequence version replaced NP_032412.2. Summary: This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. The encoded precursor protein undergoes proteolytic cleavage to produce a disulfide-linked heterodimeric functional protein that is stored in secretory granules. An increase in blood glucose levels, among others, induces the release of insulin from the secretory granules. Mice deficient in the functional hormone encoded by this gene develop diabetes mellitus. [provided by RefSeq, Aug 2015]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Gene record to access additional publications. ##Evidence-Data-START## Transcript exon combination :: BP773571.1, BQ287625.1 [ECO:0000332] RNAseq introns :: single sample supports all introns SAMN00849374, SAMN00849377 [ECO:0000348] ##Evidence-Data-END## ##RefSeq-Attributes-START## RefSeq Select criteria :: based on single protein-coding transcript ##RefSeq-Attributes-END## FEATURES Location/Qualifiers source 1..108 /organism="Mus musculus" /strain="C57BL/6" /db_xref="taxon:10090" /chromosome="19" /map="19 46.76 cM" Protein 1..108 /product="insulin-1 preproprotein" /note="insulin-1" /calculated_mol_wt=9492 sig_peptide 1..24 /note="/evidence=ECO:0000269|PubMed:5063718; propagated from UniProtKB/Swiss-Prot (P01325.1)" /calculated_mol_wt=2686 proprotein 24..108 /product="insulin-1 proprotein" /experiment="experimental evidence[PMID: 5063718]" /calculated_mol_wt=9563 mat_peptide 25..54 /product="Insulin-1 B chain. /id=PRO_0000015842" /note="propagated from UniProtKB/Swiss-Prot (P01325.1)" /calculated_mol_wt=3440 Region 26..108 /region_name="IlGF_insulin_like" /note="IlGF_like family, insulin_like subgroup, specific to vertebrates. Members include a number of peptides including insulin and insulin-like growth factors I and II, which play a variety of roles in controlling processes such as metabolism, growth and...; cd04367" /db_xref="CDD:239833" Site order(32,35,37,106) /site_type="active" /note="putative receptor binding surface [active]" /db_xref="CDD:239833" mat_peptide 88..108 /product="Insulin-1 A chain. /id=PRO_0000015844" /note="propagated from UniProtKB/Swiss-Prot (P01325.1)" /calculated_mol_wt=2370 CDS 1..108 /gene="Ins1" /gene_synonym="Ins-1; Ins2-rs1" /coded_by="NM_008386.4:210..536" /db_xref="CCDS:CCDS29898.1" /db_xref="GeneID:16333" /db_xref="MGI:MGI:96572" ORIGIN 1 mallvhflpl lallalwepk ptqafvkqhl cgphlvealy lvcgergffy tpksrreved 61 pqveqlelgg spgdlqtlal evarqkrgiv dqcctsicsl yqlenycn //