PMID- 10203281
OWN - NLM
STAT- MEDLINE
DCOM- 19990420
LR  - 20220408
IS  - 0027-8874 (Print)
IS  - 0027-8874 (Linking)
VI  - 91
IP  - 7
DP  - 1999 Apr 7
TI  - Prospective study of colorectal cancer risk in men and plasma levels of 
      insulin-like growth factor (IGF)-I and IGF-binding protein-3.
PG  - 620-5
AB  - BACKGROUND: Insulin-like growth factor-I (IGF-I) is a potent mitogen for normal 
      and neoplastic cells, whereas IGF-binding protein-3 (IGFBP-3) inhibits cell 
      growth in many experimental systems. Acromegalics, who have abnormally high 
      levels of growth hormone and IGF-I, have higher rates of colorectal cancer. We 
      therefore examined associations of plasma levels of IGF-I and IGFBP-3 with the 
      risk of colorectal cancer in a prospective case-control study nested in the 
      Physicians' Health Study. METHODS: Plasma samples were collected at baseline from 
      14916 men without diagnosed cancer. IGF-I, IGF-II, and IGFBP-3 were assayed among 
      193 men later diagnosed with colorectal cancer during 14 years of follow-up and 
      among 318 age- and smoking-matched control subjects. All P values are two-sided. 
      RESULTS: IGFBP-3 levels correlated with IGF-I levels (r=.64) and with IGF-II 
      levels (r=.90). After controlling for IGFBP-3, age, smoking, body mass index 
      (weight in kg/[height in m]2), and alcohol intake, men in the highest quintile 
      for IGF-I had an increased risk of colorectal cancer compared with men in the 
      lowest quintile (relative risk [RR]=2.51; 95% confidence interval [CI]=1.15-5.46; 
      P for trend = .02). After controlling for IGF-I and other covariates, men with 
      higher IGFBP-3 had a lower risk (RR=0.28; 95% CI=0.12-0.66; P for trend = .005, 
      comparing extreme quintiles). The associations were consistent during the first 
      and the second 7-year follow-up intervals and among younger and older men. IGF-II 
      was not associated with risk. CONCLUSIONS: Our findings suggest that circulating 
      IGF-I and IGFBP-3 are related to future risk of colorectal cancer.
FAU - Ma, J
AU  - Ma J
AD  - Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 
      Boston, MA 02115, USA. Jing.Ma@channing.harvard.edu
FAU - Pollak, M N
AU  - Pollak MN
FAU - Giovannucci, E
AU  - Giovannucci E
FAU - Chan, J M
AU  - Chan JM
FAU - Tao, Y
AU  - Tao Y
FAU - Hennekens, C H
AU  - Hennekens CH
FAU - Stampfer, M J
AU  - Stampfer MJ
LA  - eng
GR  - CA40360/CA/NCI NIH HHS/United States
GR  - CA42182/CA/NCI NIH HHS/United States
GR  - CA78293/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 67763-97-7 (Insulin-Like Growth Factor II)
SB  - IM
CIN - J Natl Cancer Inst. 1999 Apr 7;91(7):579-81. doi: 10.1093/jnci/91.7.579. PMID: 
      10203270
CIN - J Natl Cancer Inst. 1999 Dec 1;91(23):2051-2. doi: 10.1093/jnci/91.23.2051. PMID: 
      10580038
MH  - Case-Control Studies
MH  - Colorectal Neoplasms/*blood
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/*metabolism
MH  - Insulin-Like Growth Factor II/metabolism
MH  - Male
MH  - Middle Aged
MH  - Prospective Studies
MH  - Risk
MH  - Risk Factors
EDAT- 1999/04/15 02:02
MHDA- 2000/02/19 09:00
CRDT- 1999/04/15 02:02
PHST- 1999/04/15 02:02 [pubmed]
PHST- 2000/02/19 09:00 [medline]
PHST- 1999/04/15 02:02 [entrez]
AID - 10.1093/jnci/91.7.620 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 1999 Apr 7;91(7):620-5. doi: 10.1093/jnci/91.7.620.