PMID- 10373119
OWN - NLM
STAT- MEDLINE
DCOM- 19990707
LR  - 20220309
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 284
IP  - 5422
DP  - 1999 Jun 18
TI  - Vessel cooption, regression, and growth in tumors mediated by angiopoietins and 
      VEGF.
PG  - 1994-8
AB  - In contrast with the prevailing view that most tumors and metastases begin as 
      avascular masses, evidence is presented here that a subset of tumors instead 
      initially grows by coopting existing host vessels. This coopted host vasculature 
      does not immediately undergo angiogenesis to support the tumor but instead 
      regresses, leading to a secondarily avascular tumor and massive tumor cell loss. 
      Ultimately, however, the remaining tumor is rescued by robust angiogenesis at the 
      tumor margin. The expression patterns of the angiogenic antagonist angiopoietin-2 
      and of pro-angiogenic vascular endothelial growth factor (VEGF) suggest that 
      these proteins may be critical regulators of this balance between vascular 
      regression and growth.
FAU - Holash, J
AU  - Holash J
AD  - Regeneron Pharmaceuticals, 777 Old Saw Mill River Road, Tarrytown, NY 10591, USA.
FAU - Maisonpierre, P C
AU  - Maisonpierre PC
FAU - Compton, D
AU  - Compton D
FAU - Boland, P
AU  - Boland P
FAU - Alexander, C R
AU  - Alexander CR
FAU - Zagzag, D
AU  - Zagzag D
FAU - Yancopoulos, G D
AU  - Yancopoulos GD
FAU - Wiegand, S J
AU  - Wiegand SJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Angiopoietin-1)
RN  - 0 (Angiopoietin-2)
RN  - 0 (Angpt1 protein, mouse)
RN  - 0 (Angpt1 protein, rat)
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Lymphokines)
RN  - 0 (Membrane Glycoproteins)
RN  - 0 (Proteins)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
SB  - IM
MH  - Adenocarcinoma/blood supply/pathology
MH  - Angiopoietin-1
MH  - Angiopoietin-2
MH  - Animals
MH  - Apoptosis
MH  - Blood Vessels/pathology
MH  - Endothelial Growth Factors/genetics/*physiology
MH  - Endothelium, Vascular/pathology/physiology
MH  - Glioblastoma/blood supply/pathology
MH  - Glioma/blood supply/pathology
MH  - In Situ Hybridization
MH  - Lymphokines/genetics/*physiology
MH  - Male
MH  - Membrane Glycoproteins/genetics/*physiology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Muscle, Smooth, Vascular/pathology/physiology
MH  - Neoplasm Transplantation
MH  - Neoplasms, Experimental/*blood supply/*pathology
MH  - *Neovascularization, Pathologic
MH  - Proteins/genetics/*physiology
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Up-Regulation
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
EDAT- 1999/06/18 00:00
MHDA- 1999/06/18 00:01
CRDT- 1999/06/18 00:00
PHST- 1999/06/18 00:00 [pubmed]
PHST- 1999/06/18 00:01 [medline]
PHST- 1999/06/18 00:00 [entrez]
AID - 7601 [pii]
AID - 10.1126/science.284.5422.1994 [doi]
PST - ppublish
SO  - Science. 1999 Jun 18;284(5422):1994-8. doi: 10.1126/science.284.5422.1994.