PMID- 10407127
OWN - NLM
STAT- MEDLINE
DCOM- 19990831
LR  - 20240109
VI  - 30
IP  - 1
DP  - 1999 Jul
TI  - Neuroglial activation repertoire in the injured brain: graded response, molecular 
      mechanisms and cues to physiological function.
PG  - 77-105
AB  - Damage to the central nervous system (CNS) leads to cellular changes not only in 
      the affected neurons but also in adjacent glial cells and endothelia, and 
      frequently, to a recruitment of cells of the immune system. These cellular 
      changes form a graded response which is a consistent feature in almost all forms 
      of brain pathology. It appears to reflect an evolutionarily conserved program 
      which plays an important role in the protection against infectious pathogens and 
      the repair of the injured nervous system. Moreover, recent work in mice that are 
      genetically deficient for different cytokines (MCSF, IL1, IL6, TNFalpha, 
      TGFbeta1) has begun to shed light on the molecular signals that regulate this 
      cellular response. Here we will review this work and the insights it provides 
      about the biological function of the neuroglial activation in the injured brain.
CI  - Copyright 1999 Elsevier Science B.V.
FAU - Raivich, G
AU  - Raivich G
AD  - Department of Neuromorphology, Max-Planck Institute for Neurobiology, Am 
      Klopferspitz 18A, D-82152 Martinsried, Germany. raivich@neuro.mpg.de
FAU - Bohatschek, M
AU  - Bohatschek M
FAU - Kloss, C U
AU  - Kloss CU
FAU - Werner, A
AU  - Werner A
FAU - Jones, L L
AU  - Jones LL
FAU - Kreutzberg, G W
AU  - Kreutzberg GW
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Brain Res Brain Res Rev
JT  - Brain research. Brain research reviews
JID - 8908638
SB  - IM
MH  - Animals
MH  - Astrocytes/physiology
MH  - Brain/blood supply
MH  - Brain Injuries/pathology/*physiopathology
MH  - *Cues
MH  - Humans
MH  - Leukocytes/physiology
MH  - Macrophage Activation
MH  - *Nervous System Physiological Phenomena
MH  - Neuroglia/*physiology
RF  - 313
EDAT- 1999/07/17 00:00
MHDA- 1999/07/17 00:01
CRDT- 1999/07/17 00:00
PHST- 1999/07/17 00:00 [pubmed]
PHST- 1999/07/17 00:01 [medline]
PHST- 1999/07/17 00:00 [entrez]
AID - S0165017399000077 [pii]
AID - 10.1016/s0165-0173(99)00007-7 [doi]
PST - ppublish
SO  - Brain Res Brain Res Rev. 1999 Jul;30(1):77-105. doi: 
      10.1016/s0165-0173(99)00007-7.