PMID- 10615124
OWN - NLM
STAT- MEDLINE
DCOM- 20000210
LR  - 20190524
IS  - 1061-4036 (Print)
IS  - 1061-4036 (Linking)
VI  - 24
IP  - 1
DP  - 2000 Jan
TI  - Control of endodermal endocrine development by Hes-1.
PG  - 36-44
AB  - Development of endocrine cells in the endoderm involves Atonal and 
      Achaete/Scute-related basic helix-loop-helix (bHLH) proteins. These proteins also 
      serve as neuronal determination and differentiation factors, and are antagonized 
      by the Notch pathway partly acting through Hairy and Enhancer-of-split (HES)-type 
      proteins. Here we show that mice deficient in Hes1 (encoding Hes-1) display 
      severe pancreatic hypoplasia caused by depletion of pancreatic epithelial 
      precursors due to accelerated differentiation of post-mitotic endocrine cells 
      expressing glucagon. Moreover, upregulation of several bHLH components is 
      associated with precocious and excessive differentiation of multiple endocrine 
      cell types in the developing stomach and gut, showing that Hes-1 operates as a 
      general negative regulator of endodermal endocrine differentiation.
FAU - Jensen, J
AU  - Jensen J
AD  - Department of Developmental Biology, Hagedorn Research Institute, Denmark.
FAU - Pedersen, E E
AU  - Pedersen EE
FAU - Galante, P
AU  - Galante P
FAU - Hald, J
AU  - Hald J
FAU - Heller, R S
AU  - Heller RS
FAU - Ishibashi, M
AU  - Ishibashi M
FAU - Kageyama, R
AU  - Kageyama R
FAU - Guillemot, F
AU  - Guillemot F
FAU - Serup, P
AU  - Serup P
FAU - Madsen, O D
AU  - Madsen OD
LA  - eng
GR  - DK-55284/DK/NIDDK NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Genet
JT  - Nature genetics
JID - 9216904
RN  - 0 (Basic Helix-Loop-Helix Transcription Factors)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (E(spl)mdelta-HLH protein, Drosophila)
RN  - 0 (Hes1 protein, mouse)
RN  - 0 (Homeodomain Proteins)
RN  - 0 (Insect Proteins)
RN  - 0 (Membrane Proteins)
RN  - 0 (Proteins)
RN  - 0 (Receptors, Notch)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factor HES-1)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Basic Helix-Loop-Helix Transcription Factors
MH  - Cell Differentiation
MH  - DNA-Binding Proteins/metabolism
MH  - *Drosophila Proteins
MH  - Endocrine Glands/cytology/*embryology
MH  - *Endoderm
MH  - Gene Expression Regulation, Developmental
MH  - *Helix-Loop-Helix Motifs
MH  - Homeodomain Proteins/genetics/*physiology
MH  - Insect Proteins/metabolism
MH  - Intestines/pathology
MH  - Membrane Proteins/metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Molecular Sequence Data
MH  - Pancreas/embryology/pathology/physiopathology
MH  - Proteins/metabolism
MH  - Receptors, Notch
MH  - *Repressor Proteins
MH  - Signal Transduction
MH  - Stomach/pathology
MH  - Transcription Factor HES-1
EDAT- 1999/12/30 09:00
MHDA- 2001/03/23 10:01
CRDT- 1999/12/30 09:00
PHST- 1999/12/30 09:00 [pubmed]
PHST- 2001/03/23 10:01 [medline]
PHST- 1999/12/30 09:00 [entrez]
AID - 10.1038/71657 [doi]
PST - ppublish
SO  - Nat Genet. 2000 Jan;24(1):36-44. doi: 10.1038/71657.