PMID- 10655586
OWN - NLM
STAT- MEDLINE
DCOM- 20000320
LR  - 20220408
IS  - 1465-7392 (Print)
IS  - 1465-7392 (Linking)
VI  - 2
IP  - 2
DP  - 2000 Feb
TI  - The transcription factor snail controls epithelial-mesenchymal transitions by 
      repressing E-cadherin expression.
PG  - 76-83
AB  - The Snail family of transcription factors has previously been implicated in the 
      differentiation of epithelial cells into mesenchymal cells 
      (epithelial-mesenchymal transitions) during embryonic development. 
      Epithelial-mesenchymal transitions are also determinants of the progression of 
      carcinomas, occurring concomitantly with the cellular acquisition of migratory 
      properties following downregulation of expression of the adhesion protein 
      E-cadherin. Here we show that mouse Snail is a strong repressor of transcription 
      of the E-cadherin gene. Epithelial cells that ectopically express Snail adopt a 
      fibroblastoid phenotype and acquire tumorigenic and invasive properties. 
      Endogenous Snail protein is present in invasive mouse and human carcinoma cell 
      lines and tumours in which E-cadherin expression has been lost. Therefore, the 
      same molecules are used to trigger epithelial-mesenchymal transitions during 
      embryonic development and in tumour progression. Snail may thus be considered as 
      a marker for malignancy, opening up new avenues for the design of specific 
      anti-invasive drugs.
FAU - Cano, A
AU  - Cano A
AD  - Instituto de Investigaciones Biomedicas, Arturo Duperier 4, 28029 Madrid, Spain. 
      acano@iib.uam.es
FAU - Perez-Moreno, M A
AU  - Perez-Moreno MA
FAU - Rodrigo, I
AU  - Rodrigo I
FAU - Locascio, A
AU  - Locascio A
FAU - Blanco, M J
AU  - Blanco MJ
FAU - del Barrio, M G
AU  - del Barrio MG
FAU - Portillo, F
AU  - Portillo F
FAU - Nieto, M A
AU  - Nieto MA
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nat Cell Biol
JT  - Nature cell biology
JID - 100890575
RN  - 0 (Cadherins)
RN  - 0 (Cytoskeletal Proteins)
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Desmoplakins)
RN  - 0 (Repressor Proteins)
RN  - 0 (Snail Family Transcription Factors)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Animals
MH  - Binding Sites
MH  - Cadherins/biosynthesis/*genetics
MH  - Carcinoma/pathology
MH  - Carcinoma, Squamous Cell/pathology
MH  - Cell Differentiation
MH  - Cell Movement
MH  - Cytoskeletal Proteins/biosynthesis/genetics
MH  - DNA-Binding Proteins/*metabolism
MH  - Desmoplakins
MH  - Epithelial Cells/*cytology
MH  - *Gene Expression Regulation, Developmental
MH  - Humans
MH  - Keratinocytes/cytology
MH  - Mesoderm/*cytology
MH  - Mice
MH  - Neoplasm Invasiveness
MH  - Neoplasms, Glandular and Epithelial/pathology
MH  - Phenotype
MH  - Promoter Regions, Genetic
MH  - Protein Binding
MH  - Repressor Proteins/*metabolism
MH  - Snail Family Transcription Factors
MH  - Transcription Factors/*metabolism
MH  - Tumor Cells, Cultured
EDAT- 2000/02/03 09:00
MHDA- 2000/03/25 09:00
CRDT- 2000/02/03 09:00
PHST- 2000/02/03 09:00 [pubmed]
PHST- 2000/03/25 09:00 [medline]
PHST- 2000/02/03 09:00 [entrez]
AID - 10.1038/35000025 [doi]
PST - ppublish
SO  - Nat Cell Biol. 2000 Feb;2(2):76-83. doi: 10.1038/35000025.