PMID- 10689302 OWN - NLM STAT- MEDLINE DCOM- 20000414 LR - 20220228 IS - 0167-5699 (Print) IS - 0167-5699 (Linking) VI - 21 IP - 3 DP - 2000 Mar TI - Regulation of T-cell responses by CNS antigen-presenting cells: different roles for microglia and astrocytes. PG - 141-7 AB - Analysis of the mechanisms underlying CNS immune surveillance and immunopathology have provided new insights into the intracerebral regulation of immune responses. Here, Francesca Aloisi, Francesco Ria and Luciano Adorini review the role of CNS antigen presenting cells and focus on the control of Th1 and Th2 responses by microglia and astrocytes. FAU - Aloisi, F AU - Aloisi F AD - The Laboratory of Organ and System Pathophysiology, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy. FAU - Ria, F AU - Ria F FAU - Adorini, L AU - Adorini L LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review PL - England TA - Immunol Today JT - Immunology today JID - 8008346 SB - IM MH - Animals MH - Antigen-Presenting Cells/*immunology MH - Astrocytes/*immunology MH - Central Nervous System/immunology MH - Humans MH - Microglia/*immunology MH - Models, Biological MH - Neuroimmunomodulation MH - T-Lymphocytes/*immunology RF - 47 EDAT- 2000/02/26 09:00 MHDA- 2000/04/25 09:00 CRDT- 2000/02/26 09:00 PHST- 2000/02/26 09:00 [pubmed] PHST- 2000/04/25 09:00 [medline] PHST- 2000/02/26 09:00 [entrez] AID - S0167-5699(99)01512-1 [pii] AID - 10.1016/s0167-5699(99)01512-1 [doi] PST - ppublish SO - Immunol Today. 2000 Mar;21(3):141-7. doi: 10.1016/s0167-5699(99)01512-1.