PMID- 10695732
OWN - NLM
STAT- MEDLINE
DCOM- 20000309
LR  - 20230413
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 100
IP  - 1-2
DP  - 1999 Dec
TI  - Immune defects observed in patients with primary malignant brain tumors.
PG  - 216-32
AB  - Malignant glioblastomas (gliomas) account for approximately one third of all 
      diagnosed brain tumors. Yet, a decade of research has made little progress in 
      advancing the treatment of these tumors. In part this lack of progress is linked 
      to the challenge of discovering how glial tumors are capable of both modulating 
      host immune function and neutralizing immune-based therapies. Patients with 
      gliomas exhibit a broad suppression of cell-mediated immunity. The impaired 
      cell-mediated immunity observed in patients with gliomas appears to result from 
      immunosuppressive factor(s) secreted by the tumor. This article reviews what has 
      been elucidated about the immune defects of patients harboring glioma and the 
      glioma-derived factors which mediate this immunosuppression. A model involving 
      systemic cytokine dysregulation is presented to suggest how the immune defects 
      arise in these individuals.
FAU - Dix, A R
AU  - Dix AR
AD  - Department of Microbiology and Immunology, University of Kentucky Medical Center, 
      Lexington 40536-0084, USA.
FAU - Brooks, W H
AU  - Brooks WH
FAU - Roszman, T L
AU  - Roszman TL
FAU - Morford, L A
AU  - Morford LA
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Receptors, Interleukin-2)
RN  - 0 (Transforming Growth Factor beta)
RN  - 130068-27-8 (Interleukin-10)
RN  - K7Q1JQR04M (Dinoprostone)
SB  - IM
MH  - Apoptosis
MH  - Brain Neoplasms/*immunology
MH  - Dinoprostone/immunology
MH  - Glioblastoma/*immunology
MH  - Glioma/*immunology
MH  - Humans
MH  - Interleukin-10/immunology
MH  - Killer Cells, Natural/immunology
MH  - Monocytes/immunology
MH  - Receptors, Interleukin-2/immunology
MH  - Signal Transduction
MH  - T-Lymphocytes/immunology
MH  - Transforming Growth Factor beta/immunology
RF  - 220
EDAT- 2000/03/01 09:00
MHDA- 2000/06/01 09:00
CRDT- 2000/03/01 09:00
PHST- 2000/03/01 09:00 [pubmed]
PHST- 2000/06/01 09:00 [medline]
PHST- 2000/03/01 09:00 [entrez]
AID - S0165572899002039 [pii]
AID - 10.1016/s0165-5728(99)00203-9 [doi]
PST - ppublish
SO  - J Neuroimmunol. 1999 Dec;100(1-2):216-32. doi: 10.1016/s0165-5728(99)00203-9.