PMID- 10704459
OWN - NLM
STAT- MEDLINE
DCOM- 20000404
LR  - 20240213
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 191
IP  - 5
DP  - 2000 Mar 6
TI  - Reversible defects in natural killer and memory CD8 T cell lineages in 
      interleukin 15-deficient mice.
PG  - 771-80
AB  - C57BL/6 mice genetically deficient in interleukin 15 (IL-15(-/-) mice) were 
      generated by gene targeting. IL-15(-/-) mice displayed marked reductions in 
      numbers of thymic and peripheral natural killer (NK) T cells, memory phenotype 
      CD8(+) T cells, and distinct subpopulations of intestinal intraepithelial 
      lymphocytes (IELs). The reduction but not absence of these populations in 
      IL-15(-/-) mice likely reflects an important role for IL-15 for expansion and/or 
      survival of these cells. IL-15(-/-) mice lacked NK cells, as assessed by both 
      immunophenotyping and functional criteria, indicating an obligate role for IL-15 
      in the development and functional maturation of NK cells. Specific defects 
      associated with IL-15 deficiency were reversed by in vivo administration of 
      exogenous IL-15. Despite their immunological defects, IL-15(-/-) mice remained 
      healthy when maintained under specific pathogen-free conditions. However, 
      IL-15(-/-) mice are likely to have compromised host defense responses to various 
      pathogens, as they were unable to mount a protective response to challenge with 
      vaccinia virus. These data reveal critical roles for IL-15 in the development of 
      specific lymphoid lineages. Moreover, the ability to rescue lymphoid defects in 
      IL-15(-/-) mice by IL-15 administration represents a powerful means by which to 
      further elucidate the biological roles of this cytokine.
FAU - Kennedy, M K
AU  - Kennedy MK
AD  - Immunex Corporation, Seattle, Washington 98101, USA.
FAU - Glaccum, M
AU  - Glaccum M
FAU - Brown, S N
AU  - Brown SN
FAU - Butz, E A
AU  - Butz EA
FAU - Viney, J L
AU  - Viney JL
FAU - Embers, M
AU  - Embers M
FAU - Matsuki, N
AU  - Matsuki N
FAU - Charrier, K
AU  - Charrier K
FAU - Sedger, L
AU  - Sedger L
FAU - Willis, C R
AU  - Willis CR
FAU - Brasel, K
AU  - Brasel K
FAU - Morrissey, P J
AU  - Morrissey PJ
FAU - Stocking, K
AU  - Stocking K
FAU - Schuh, J C
AU  - Schuh JC
FAU - Joyce, S
AU  - Joyce S
FAU - Peschon, J J
AU  - Peschon JJ
LA  - eng
GR  - R01 AI042284/AI/NIAID NIH HHS/United States
GR  - R21 AI042284/AI/NIAID NIH HHS/United States
GR  - AI42284/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Il15ra protein, mouse)
RN  - 0 (Interleukin-15)
RN  - 0 (Receptors, Interleukin-15)
RN  - 0 (Receptors, Interleukin-2)
SB  - IM
CIN - J Exp Med. 2000 Mar 6;191(5):753-6. PMID: 10704456
MH  - Animals
MH  - CD8-Positive T-Lymphocytes/*immunology
MH  - Cell Lineage
MH  - Epithelial Cells/immunology
MH  - Female
MH  - *Immunologic Memory
MH  - Interleukin-15/genetics/*immunology
MH  - Killer Cells, Natural/*immunology
MH  - Lymph Nodes/anatomy & histology/immunology
MH  - Lymphocyte Count
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Mutant Strains
MH  - Organ Size
MH  - Receptors, Interleukin-15
MH  - Receptors, Interleukin-2/genetics/*immunology
MH  - Spleen/anatomy & histology/immunology
MH  - Thymus Gland/anatomy & histology/immunology
MH  - Vaccinia/mortality
PMC - PMC2195858
EDAT- 2000/03/08 00:00
MHDA- 2000/03/08 00:01
PMCR- 2000/09/06
CRDT- 2000/03/08 00:00
PHST- 2000/03/08 00:00 [pubmed]
PHST- 2000/03/08 00:01 [medline]
PHST- 2000/03/08 00:00 [entrez]
PHST- 2000/09/06 00:00 [pmc-release]
AID - 991960 [pii]
AID - 10.1084/jem.191.5.771 [doi]
PST - ppublish
SO  - J Exp Med. 2000 Mar 6;191(5):771-80. doi: 10.1084/jem.191.5.771.