PMID- 10737798
OWN - NLM
STAT- MEDLINE
DCOM- 20000424
LR  - 20240914
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 97
IP  - 7
DP  - 2000 Mar 28
TI  - Deregulated expression of insulin-like growth factor 1 in prostate epithelium 
      leads to neoplasia in transgenic mice.
PG  - 3455-60
AB  - Transgenic mice expressing human insulin-like growth factor 1 (IGF-1) in basal 
      epithelial cells of prostate have been characterized. Transgene expression led to 
      activation of the IGF-1 receptor and spontaneous tumorigenesis in prostate 
      epithelium. Hyperplasia was evident in these mice by 2-3 months of age. Atypical 
      hyperplasias and prostatic intraepithelial neoplasia were evident by 6-7 months 
      of age. Well differentiated adenocarcinomas appeared in mice 6 months or older. 
      Less differentiated tumors, diagnosed as small cell carcinomas, were also 
      observed in two of the older mice. Both lobes of the mouse prostate gland 
      (dorsolateral and ventral) presented preneoplastic and neoplastic changes. The 
      incidence of tumors in mice >/=6 months of age (38 mice total) was 50%. The 
      development of neoplasia in these transgenic mice appeared to follow a stepwise 
      progression through early preneoplastic changes that ultimately culminated in 
      frank neoplasia. These mice offer an animal model for prostate cancer that will 
      allow study of the stepwise development of this disease and the mechanism(s) 
      whereby IGF-1 mediates this process.
FAU - DiGiovanni, J
AU  - DiGiovanni J
AD  - Department of Carcinogenesis, The University of Texas M. D. Anderson Cancer 
      Center, Science Park, Research Division, P.O. Box 389, Smithville, TX 78957, USA. 
      sa83107@odin.mdacc.tmc.edu
FAU - Kiguchi, K
AU  - Kiguchi K
FAU - Frijhoff, A
AU  - Frijhoff A
FAU - Wilker, E
AU  - Wilker E
FAU - Bol, D K
AU  - Bol DK
FAU - Beltran, L
AU  - Beltran L
FAU - Moats, S
AU  - Moats S
FAU - Ramirez, A
AU  - Ramirez A
FAU - Jorcano, J
AU  - Jorcano J
FAU - Conti, C
AU  - Conti C
LA  - eng
GR  - P30 CA016672/CA/NCI NIH HHS/United States
GR  - R01 CA037111/CA/NCI NIH HHS/United States
GR  - CA16672/CA/NCI NIH HHS/United States
GR  - P30 ES007784/ES/NIEHS NIH HHS/United States
GR  - CA37111/CA/NCI NIH HHS/United States
GR  - ES07784/ES/NIEHS NIH HHS/United States
GR  - T32 ES007247/ES/NIEHS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Animals
MH  - Epithelial Cells/metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - Insulin-Like Growth Factor I/*genetics
MH  - Male
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Mice, Transgenic
MH  - Prostate/*metabolism
MH  - Prostatic Neoplasms/*genetics
PMC - PMC16261
EDAT- 2000/03/29 09:00
MHDA- 2000/04/29 09:00
PMCR- 2000/09/28
CRDT- 2000/03/29 09:00
PHST- 2000/03/29 09:00 [pubmed]
PHST- 2000/04/29 09:00 [medline]
PHST- 2000/03/29 09:00 [entrez]
PHST- 2000/09/28 00:00 [pmc-release]
AID - 97/7/3455 [pii]
AID - 0284 [pii]
AID - 10.1073/pnas.97.7.3455 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3455-60. doi: 10.1073/pnas.97.7.3455.