PMID- 10858586
OWN - NLM
STAT- MEDLINE
DCOM- 20000907
LR  - 20240226
IS  - 0197-4580 (Print)
IS  - 1558-1497 (Electronic)
IS  - 0197-4580 (Linking)
VI  - 21
IP  - 3
DP  - 2000 May-Jun
TI  - Inflammation and Alzheimer's disease.
PG  - 383-421
AB  - Inflammation clearly occurs in pathologically vulnerable regions of the 
      Alzheimer's disease (AD) brain, and it does so with the full complexity of local 
      peripheral inflammatory responses. In the periphery, degenerating tissue and the 
      deposition of highly insoluble abnormal materials are classical stimulants of 
      inflammation. Likewise, in the AD brain damaged neurons and neurites and highly 
      insoluble amyloid beta peptide deposits and neurofibrillary tangles provide 
      obvious stimuli for inflammation. Because these stimuli are discrete, 
      microlocalized, and present from early preclinical to terminal stages of AD, 
      local upregulation of complement, cytokines, acute phase reactants, and other 
      inflammatory mediators is also discrete, microlocalized, and chronic. Cumulated 
      over many years, direct and bystander damage from AD inflammatory mechanisms is 
      likely to significantly exacerbate the very pathogenic processes that gave rise 
      to it. Thus, animal models and clinical studies, although still in their infancy, 
      strongly suggest that AD inflammation significantly contributes to AD 
      pathogenesis. By better understanding AD inflammatory and immunoregulatory 
      processes, it should be possible to develop anti-inflammatory approaches that may 
      not cure AD but will likely help slow the progression or delay the onset of this 
      devastating disorder.
FAU - Akiyama, H
AU  - Akiyama H
AD  - Sun Health Research Institute, 10515 West Santa Fe Drive, P.O. Box 1278, 85372, 
      Sun City, AZ, USA.
FAU - Barger, S
AU  - Barger S
FAU - Barnum, S
AU  - Barnum S
FAU - Bradt, B
AU  - Bradt B
FAU - Bauer, J
AU  - Bauer J
FAU - Cole, G M
AU  - Cole GM
FAU - Cooper, N R
AU  - Cooper NR
FAU - Eikelenboom, P
AU  - Eikelenboom P
FAU - Emmerling, M
AU  - Emmerling M
FAU - Fiebich, B L
AU  - Fiebich BL
FAU - Finch, C E
AU  - Finch CE
FAU - Frautschy, S
AU  - Frautschy S
FAU - Griffin, W S
AU  - Griffin WS
FAU - Hampel, H
AU  - Hampel H
FAU - Hull, M
AU  - Hull M
FAU - Landreth, G
AU  - Landreth G
FAU - Lue, L
AU  - Lue L
FAU - Mrak, R
AU  - Mrak R
FAU - Mackenzie, I R
AU  - Mackenzie IR
FAU - McGeer, P L
AU  - McGeer PL
FAU - O'Banion, M K
AU  - O'Banion MK
FAU - Pachter, J
AU  - Pachter J
FAU - Pasinetti, G
AU  - Pasinetti G
FAU - Plata-Salaman, C
AU  - Plata-Salaman C
FAU - Rogers, J
AU  - Rogers J
FAU - Rydel, R
AU  - Rydel R
FAU - Shen, Y
AU  - Shen Y
FAU - Streit, W
AU  - Streit W
FAU - Strohmeyer, R
AU  - Strohmeyer R
FAU - Tooyoma, I
AU  - Tooyoma I
FAU - Van Muiswinkel, F L
AU  - Van Muiswinkel FL
FAU - Veerhuis, R
AU  - Veerhuis R
FAU - Walker, D
AU  - Walker D
FAU - Webster, S
AU  - Webster S
FAU - Wegrzyniak, B
AU  - Wegrzyniak B
FAU - Wenk, G
AU  - Wenk G
FAU - Wyss-Coray, T
AU  - Wyss-Coray T
LA  - eng
GR  - P01 AG012411/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Neurobiol Aging
JT  - Neurobiology of aging
JID - 8100437
SB  - IM
MH  - Alzheimer Disease/*pathology
MH  - Brain/pathology
MH  - Humans
MH  - Inflammation/*pathology
PMC - PMC3887148
MID - NIHMS542954
EDAT- 2000/06/20 09:00
MHDA- 2000/09/09 11:01
PMCR- 2014/01/09
CRDT- 2000/06/20 09:00
PHST- 2000/06/20 09:00 [pubmed]
PHST- 2000/09/09 11:01 [medline]
PHST- 2000/06/20 09:00 [entrez]
PHST- 2014/01/09 00:00 [pmc-release]
AID - S019745800000124X [pii]
AID - 10.1016/s0197-4580(00)00124-x [doi]
PST - ppublish
SO  - Neurobiol Aging. 2000 May-Jun;21(3):383-421. doi: 10.1016/s0197-4580(00)00124-x.