PMID- 10954453
OWN - NLM
STAT- MEDLINE
DCOM- 20001003
LR  - 20220408
IS  - 0361-803X (Print)
IS  - 0361-803X (Linking)
VI  - 175
IP  - 3
DP  - 2000 Sep
TI  - Comparison of CT findings with resected specimens after chemoembolization with 
      iodized oil for hepatocellular carcinoma.
PG  - 699-704
AB  - OBJECTIVE: We assessed the role of dynamic CT in the evaluation of the efficacy 
      of transarterial chemoembolization with iodized oil for hepatocellular carcinoma. 
      MATERIALS AND METHODS: We examined 41 hepatocellular carcinoma lesions (mean 
      diameter, 5.0 cm) in 40 patients (mean age, 60.6 years) who underwent 
      transarterial injection of iodized oil alone (n = 3) or emulsion of iodized oil 
      and doxorubicin hydrochloride (n = 10) followed by gelatin sponge particles (n = 
      27) and subsequent hepatectomy. On dynamic CT performed within 3 weeks before 
      oily transarterial chemoembolization and within 4 weeks before surgery, we 
      calculated the rate of necrosis on the basis of the assumption that the portion 
      that retained iodized oil represented necrosis. We also calculated the reduction 
      rate of the tumor. CT findings were compared with pathologic findings of resected 
      specimens. RESULTS: Pathologic specimens and the necrosis rate measured on CT 
      showed a good correlation (r = 0.83) when the portion of tumor that retained 
      iodized oil was considered necrosis. No correlation existed if the portion that 
      retained iodized oil was considered viable. We noted no significant correlation 
      (r = 0.38) between the reduction rate of the tumor and necrosis rate. Also, we 
      noted no correlation (r = 0.52) between the interval between transarterial oily 
      chemoembolization and surgery and the reduction rate of the tumor. CONCLUSION: CT 
      is suitable for the evaluation of the efficacy of oily chemoembolization for 
      hepatocellular carcinoma on the basis of the assumption that the portion of tumor 
      that retains iodized oil is necrotic. The rate of tumor size reduction measured 
      on CT did not correlate with the therapeutic effect of chemoembolization.
FAU - Takayasu, K
AU  - Takayasu K
AD  - Department of Diagnostic Radiology, National Cancer Center Hospital, 5-1-1, 
      Tsukiji, Chuo-ku, Tokyo 114-0045, Japan.
FAU - Arii, S
AU  - Arii S
FAU - Matsuo, N
AU  - Matsuo N
FAU - Yoshikawa, M
AU  - Yoshikawa M
FAU - Ryu, M
AU  - Ryu M
FAU - Takasaki, K
AU  - Takasaki K
FAU - Sato, M
AU  - Sato M
FAU - Yamanaka, N
AU  - Yamanaka N
FAU - Shimamura, Y
AU  - Shimamura Y
FAU - Ohto, M
AU  - Ohto M
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AJR Am J Roentgenol
JT  - AJR. American journal of roentgenology
JID - 7708173
RN  - 0 (Antineoplastic Agents)
RN  - 8001-40-9 (Iodized Oil)
RN  - 80168379AG (Doxorubicin)
SB  - IM
MH  - Aged
MH  - Antineoplastic Agents/administration & dosage
MH  - Carcinoma, Hepatocellular/*diagnostic imaging/*therapy
MH  - *Chemoembolization, Therapeutic
MH  - Doxorubicin/administration & dosage
MH  - Female
MH  - Humans
MH  - Iodized Oil/administration & dosage
MH  - Liver Neoplasms/*diagnostic imaging/*therapy
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Tomography, X-Ray Computed
EDAT- 2000/08/23 11:00
MHDA- 2000/10/07 11:01
CRDT- 2000/08/23 11:00
PHST- 2000/08/23 11:00 [pubmed]
PHST- 2000/10/07 11:01 [medline]
PHST- 2000/08/23 11:00 [entrez]
AID - 10.2214/ajr.175.3.1750699 [doi]
PST - ppublish
SO  - AJR Am J Roentgenol. 2000 Sep;175(3):699-704. doi: 10.2214/ajr.175.3.1750699.