PMID- 10995803
OWN - NLM
STAT- MEDLINE
DCOM- 20001228
LR  - 20220719
IS  - 0027-8874 (Print)
IS  - 0027-8874 (Linking)
VI  - 92
IP  - 18
DP  - 2000 Sep 20
TI  - Role of the insulin-like growth factor family in cancer development and 
      progression.
PG  - 1472-89
AB  - The insulin-like growth factors (IGFs) are mitogens that play a pivotal role in 
      regulating cell proliferation, differentiation, and apoptosis. The effects of 
      IGFs are mediated through the IGF-I receptor, which is also involved in cell 
      transformation induced by tumor virus proteins and oncogene products. Six 
      IGF-binding proteins (IGFBPs) can inhibit or enhance the actions of IGFs. These 
      opposing effects are determined by the structures of the binding proteins. The 
      effects of IGFBPs on IGFs are regulated in part by IGFBP proteases. Laboratory 
      studies have shown that IGFs exert strong mitogenic and antiapoptotic actions on 
      various cancer cells. IGFs also act synergistically with other mitogenic growth 
      factors and steroids and antagonize the effect of antiproliferative molecules on 
      cancer growth. The role of IGFs in cancer is supported by epidemiologic studies, 
      which have found that high levels of circulating IGF-I and low levels of IGFBP-3 
      are associated with increased risk of several common cancers, including those of 
      the prostate, breast, colorectum, and lung. Evidence further suggests that 
      certain lifestyles, such as one involving a high-energy diet, may increase IGF-I 
      levels, a finding that is supported by animal experiments indicating that IGFs 
      may abolish the inhibitory effect of energy restriction on cancer growth. Further 
      investigation of the role of IGFs in linking high energy intake, increased cell 
      proliferation, suppression of apoptosis, and increased cancer risk may provide 
      new insights into the etiology of cancer and lead to new strategies for cancer 
      prevention.
FAU - Yu, H
AU  - Yu H
AD  - Feist-Weiller Cancer Center, Louisiana State University Health Sciences Center, 
      Shreveport 71130-3932, USA. hyu@lsumc.edu
FAU - Rohan, T
AU  - Rohan T
LA  - eng
GR  - CA80704/CA/NCI NIH HHS/United States
GR  - CA83050/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - J Natl Cancer Inst
JT  - Journal of the National Cancer Institute
JID - 7503089
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 0 (Receptors, Somatomedin)
RN  - 0 (Somatomedins)
SB  - IM
CIN - J Natl Cancer Inst. 2001 Feb 7;93(3):238. doi: 10.1093/jnci/93.3.238. PMID: 
      11158195
MH  - Age Factors
MH  - Alcohol Drinking
MH  - Animals
MH  - Apoptosis
MH  - Case-Control Studies
MH  - Cell Division
MH  - Disease Progression
MH  - Energy Intake
MH  - Epidemiologic Studies
MH  - Exercise
MH  - Feeding Behavior
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Proteins/*metabolism
MH  - Life Style
MH  - Neoplasms/*etiology/*metabolism
MH  - Predictive Value of Tests
MH  - Prognosis
MH  - Receptors, Somatomedin/metabolism
MH  - Sex Factors
MH  - Smoking
MH  - Somatomedins/*metabolism
RF  - 315
EDAT- 2000/09/21 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/09/21 11:00
PHST- 2000/09/21 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/09/21 11:00 [entrez]
AID - 10.1093/jnci/92.18.1472 [doi]
PST - ppublish
SO  - J Natl Cancer Inst. 2000 Sep 20;92(18):1472-89. doi: 10.1093/jnci/92.18.1472.