PMID- 11001068
OWN - NLM
STAT- MEDLINE
DCOM- 20001019
LR  - 20240109
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 407
IP  - 6801
DP  - 2000 Sep 14
TI  - Angiogenesis in cancer and other diseases.
PG  - 249-57
AB  - Pathological angiogenesis is a hallmark of cancer and various ischaemic and 
      inflammatory diseases. Concentrated efforts in this area of research are leading 
      to the discovery of a growing number of pro- and anti-angiogenic molecules, some 
      of which are already in clinical trials. The complex interactions among these 
      molecules and how they affect vascular structure and function in different 
      environments are now beginning to be elucidated. This integrated understanding is 
      leading to the development of a number of exciting and bold approaches to treat 
      cancer and other diseases. But owing to several unanswered questions, caution is 
      needed.
FAU - Carmeliet, P
AU  - Carmeliet P
AD  - The Center for Transgene Technology and Gene Therapy, Flanders Interuniversity 
      Institute for Biotechnology, KU Leuven, Belgium. 
      peter.carmeliet@med.kuleuven.ac.be
FAU - Jain, R K
AU  - Jain RK
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Endothelial Growth Factors)
RN  - 0 (Lymphokines)
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Vascular Endothelial Growth Factors)
SB  - IM
MH  - Animals
MH  - Disease
MH  - Endothelial Growth Factors/physiology
MH  - Humans
MH  - Lymphokines/physiology
MH  - Neoplasms/*blood supply/genetics
MH  - *Neovascularization, Pathologic/drug therapy/genetics
MH  - Vascular Endothelial Growth Factor A
MH  - Vascular Endothelial Growth Factors
RF  - 75
EDAT- 2000/09/23 11:00
MHDA- 2000/10/21 11:01
CRDT- 2000/09/23 11:00
PHST- 2000/09/23 11:00 [pubmed]
PHST- 2000/10/21 11:01 [medline]
PHST- 2000/09/23 11:00 [entrez]
AID - 10.1038/35025220 [doi]
PST - ppublish
SO  - Nature. 2000 Sep 14;407(6801):249-57. doi: 10.1038/35025220.