PMID- 11024536
OWN - NLM
STAT- MEDLINE
DCOM- 20001113
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 110
IP  - 1-2
DP  - 2000 Oct 2
TI  - Astrocytes and central nervous system endothelial cells do not express B7-1 
      (CD80) or B7-2 (CD86) immunoreactivity during experimental autoimmune 
      encephalomyelitis.
PG  - 76-82
AB  - The identity of cell types within the central nervous system (CNS) capable of 
      activating T lymphocytes is a fundamental issue in the understanding of multiple 
      sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE). 
      To become fully activated, a T cell must recognize its antigen and receive 
      co-stimulation, the latter being optimally delivered via B7-1 and/or B7-2 
      molecules expressed by the antigen presenting cell (APC). There are conflicting 
      reports regarding whether astrocytes or CNS endothelial cells (EC) can act as 
      fully competent APCs. The present studies were performed to determine whether 
      astrocytes or CNS EC express B7-1 or B7-2 immunoreactivity during EAE. No 
      expression of B7-1 or B7-2 by either astrocytes or EC was detected during acute, 
      remitting, relapsing or chronic EAE, whether EAE was induced by active 
      immunization or cell transfer using five different myelin antigens. These results 
      suggest that neither astrocytes nor CNS EC can deliver co-stimulatory signals via 
      B7 molecules in the setting of murine EAE, rendering them incapable of acting as 
      fully competent APCs.
FAU - Cross, A H
AU  - Cross AH
AD  - Department of Neurology and Neurosurgery, Washington University School of 
      Medicine, 660 S. Euclid Avenue, St. Louis, MO 63110, USA. crossa@neuro.wustl.edu
FAU - Ku, G
AU  - Ku G
LA  - eng
GR  - NS34947/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Antibodies)
RN  - 0 (Antigens, CD)
RN  - 0 (B7-1 Antigen)
RN  - 0 (B7-2 Antigen)
RN  - 0 (Cd86 protein, mouse)
RN  - 0 (Membrane Glycoproteins)
SB  - IM
MH  - Animals
MH  - Antibodies
MH  - Antigens, CD/*analysis/immunology
MH  - Astrocytes/*chemistry/pathology
MH  - B7-1 Antigen/*analysis/immunology
MH  - B7-2 Antigen
MH  - Brain Chemistry/immunology
MH  - Encephalomyelitis, Autoimmune, Experimental/*immunology/*pathology
MH  - Endothelium/cytology/pathology
MH  - Female
MH  - Immunoenzyme Techniques
MH  - Membrane Glycoproteins/*analysis/immunology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Recurrence
MH  - Specific Pathogen-Free Organisms
MH  - Spinal Cord/chemistry/immunology
MH  - T-Lymphocytes/immunology
EDAT- 2000/10/12 11:00
MHDA- 2001/02/28 10:01
CRDT- 2000/10/12 11:00
PHST- 2000/10/12 11:00 [pubmed]
PHST- 2001/02/28 10:01 [medline]
PHST- 2000/10/12 11:00 [entrez]
AID - S0165-5728(00)00327-1 [pii]
AID - 10.1016/s0165-5728(00)00327-1 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2000 Oct 2;110(1-2):76-82. doi: 10.1016/s0165-5728(00)00327-1.