PMID- 11224528
OWN - NLM
STAT- MEDLINE
DCOM- 20010412
LR  - 20220409
IS  - 1529-2908 (Print)
IS  - 1529-2908 (Linking)
VI  - 2
IP  - 3
DP  - 2001 Mar
TI  - B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.
PG  - 269-74
AB  - We describe here a newly identified member of the human B7 family, designated B7 
      homolog 3 (B7-H3), that shares 20-27% amino acid identity with other B7 family 
      members. B7-H3 mRNA is not detectable in peripheral blood mononuclear cells, 
      although it is found in various normal tissues and in several tumor cell lines. 
      Expression of B7-H3 protein, however, can be induced on dendritic cells (DCs) and 
      monocytes by inflammatory cytokines and a combination of phorbol myristate 
      acetate (PMA) + ionomycin. Soluble B7-H3 protein binds a putative 
      counter-receptor on activated T cells that is distinct from CD28, cytotoxic T 
      lymphocyte antigen 4 (CTLA-4), inducible costimulator (ICOS) and PD-1. B7-H3 
      costimulates proliferation of both CD4+ and CD8+ T cells, enhances the induction 
      of cytotoxic T cells and selectively stimulates interferon gamma (IFN-gamma) 
      production in the presence of T cell receptor signaling. In contrast, inclusion 
      of antisense B7-H3 oligonucleotides decreases the expression of B7-H3 on DCs and 
      inhibits IFN-gamma production by DC-stimulated allogeneic T cells.Thus, we 
      describe a newly identified costimulatory pathway that may participate in the 
      regulation of cell-mediated immune responses.
FAU - Chapoval, A I
AU  - Chapoval AI
AD  - Department of Immunology, Mayo Graduate and Medical Schools, Mayo Clinic, 
      Rochester, MN 55905, USA.
FAU - Ni, J
AU  - Ni J
FAU - Lau, J S
AU  - Lau JS
FAU - Wilcox, R A
AU  - Wilcox RA
FAU - Flies, D B
AU  - Flies DB
FAU - Liu, D
AU  - Liu D
FAU - Dong, H
AU  - Dong H
FAU - Sica, G L
AU  - Sica GL
FAU - Zhu, G
AU  - Zhu G
FAU - Tamada, K
AU  - Tamada K
FAU - Chen, L
AU  - Chen L
LA  - eng
SI  - GENBANK/AF302102
GR  - AI07425/AI/NIAID NIH HHS/United States
GR  - CA09127/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Nat Immunol
JT  - Nature immunology
JID - 100941354
RN  - 0 (Antigens, CD)
RN  - 0 (B7 Antigens)
RN  - 0 (B7-1 Antigen)
RN  - 0 (CD276 protein, human)
RN  - 0 (Cytokines)
RN  - 0 (Protein Isoforms)
RN  - 0 (Receptors, Immunologic)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Amino Acid Sequence
MH  - Antigens, CD
MH  - B7 Antigens
MH  - B7-1 Antigen/*genetics/*immunology/metabolism
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - Cytokines/biosynthesis
MH  - Dendritic Cells/immunology
MH  - Humans
MH  - Interferon-gamma/*biosynthesis
MH  - *Lymphocyte Activation
MH  - Molecular Sequence Data
MH  - Protein Isoforms/genetics
MH  - Receptors, Immunologic/immunology
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes/*immunology
MH  - T-Lymphocytes, Cytotoxic/immunology
MH  - Transcription, Genetic
MH  - Tumor Cells, Cultured
EDAT- 2001/02/27 10:00
MHDA- 2001/04/17 10:01
CRDT- 2001/02/27 10:00
PHST- 2001/02/27 10:00 [pubmed]
PHST- 2001/04/17 10:01 [medline]
PHST- 2001/02/27 10:00 [entrez]
AID - 10.1038/85339 [doi]
PST - ppublish
SO  - Nat Immunol. 2001 Mar;2(3):269-74. doi: 10.1038/85339.