PMID- 11237176
OWN - NLM
STAT- MEDLINE
DCOM- 20010607
LR  - 20220318
IS  - 0951-6433 (Print)
IS  - 0951-6433 (Linking)
VI  - 13
IP  - 1-4
DP  - 2000
TI  - Recent studies on the biofunctions and biotransformations of curcumin.
PG  - 153-8
AB  - Curcumin is a major component of Curcuma species, which is commonly used as a 
      yellow coloring and flavoring agent in foods. Curcumin has shown 
      anti-carcinogenic activity in animals as indicated by its ability to block colon 
      tumor initiation by azoxymethane and skin tumor promotion induced by phorbol 
      ester TPA. Curcumin possesses anti-inflammatory activity and is a potent 
      inhibitor of reactive oxygen-generating enzymes such as 
      lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase and inducible nitric 
      oxide synthase. Curcumin is also a potent inhibitor of protein kinase C, 
      EGF-receptor tyrosine kinase and IkappaB kinase. Subsequently, curcumin inhibits 
      the activation of NFkappaB and the expressions of c-jun, c-fos, c-myc and iNOS. 
      It is proposed that curcumin may suppress tumor promotion through blocking signal 
      transduction pathways in the target cells. Curcumin was first biotransformed to 
      dihydrocurcumin and tetrahydrocurcumin and that these compounds subsequently were 
      converted to monoglucuronide conjugates. These results suggest that 
      curcumin-glucuronide, dihydro-curcumin-glucuronide, 
      tetrahydrocurcumin-glucuronide and tetrahydrocurcumin are major metabolites of 
      curcumin in mice.
FAU - Lin, J K
AU  - Lin JK
AD  - Institutes of Biochemistry, College of Medicine, National Taiwan University, 
      Taipei. jklin@ha.mc.ntu.edu.tw
FAU - Pan, M H
AU  - Pan MH
FAU - Lin-Shiau, S Y
AU  - Lin-Shiau SY
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - Biofactors
JT  - BioFactors (Oxford, England)
JID - 8807441
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - 0 (Anticarcinogenic Agents)
RN  - 0 (Antioxidants)
RN  - 0 (Flavoring Agents)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents, Non-Steroidal/pharmacology
MH  - Anticarcinogenic Agents/pharmacology
MH  - Antioxidants/pharmacology
MH  - Biotransformation
MH  - Cell Survival/drug effects
MH  - Curcumin/pharmacokinetics/*pharmacology
MH  - Female
MH  - Flavoring Agents
MH  - Humans
MH  - Mammary Neoplasms, Experimental/prevention & control
MH  - Neoplasm Invasiveness/prevention & control
MH  - Tumor Cells, Cultured
RF  - 30
EDAT- 2001/03/10 10:00
MHDA- 2001/06/19 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/06/19 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - 10.1002/biof.5520130125 [doi]
PST - ppublish
SO  - Biofactors. 2000;13(1-4):153-8. doi: 10.1002/biof.5520130125.