PMID- 11242036
OWN - NLM
STAT- MEDLINE
DCOM- 20010329
LR  - 20240109
IS  - 0028-0836 (Print)
IS  - 0028-0836 (Linking)
VI  - 410
IP  - 6824
DP  - 2001 Mar 1
TI  - Involvement of chemokine receptors in breast cancer metastasis.
PG  - 50-6
AB  - Breast cancer is characterized by a distinct metastatic pattern involving the 
      regional lymph nodes, bone marrow, lung and liver. Tumour cell migration and 
      metastasis share many similarities with leukocyte trafficking, which is 
      critically regulated by chemokines and their receptors. Here we report that the 
      chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer 
      cells, malignant breast tumours and metastases. Their respective ligands 
      CXCL12/SDF-1alpha and CCL21/6Ckine exhibit peak levels of expression in organs 
      representing the first destinations of breast cancer metastasis. In breast cancer 
      cells, signalling through CXCR4 or CCR7 mediates actin polymerization and 
      pseudopodia formation, and subsequently induces chemotactic and invasive 
      responses. In vivo, neutralizing the interactions of CXCL12/CXCR4 significantly 
      impairs metastasis of breast cancer cells to regional lymph nodes and lung. 
      Malignant melanoma, which has a similar metastatic pattern as breast cancer but 
      also a high incidence of skin metastases, shows high expression levels of CCR10 
      in addition to CXCR4 and CCR7. Our findings indicate that chemokines and their 
      receptors have a critical role in determining the metastatic destination of 
      tumour cells.
FAU - Muller, A
AU  - Muller A
AD  - Department of Immunology, DNAX Research Institute, Palo Alto, California 94304, 
      USA.
FAU - Homey, B
AU  - Homey B
FAU - Soto, H
AU  - Soto H
FAU - Ge, N
AU  - Ge N
FAU - Catron, D
AU  - Catron D
FAU - Buchanan, M E
AU  - Buchanan ME
FAU - McClanahan, T
AU  - McClanahan T
FAU - Murphy, E
AU  - Murphy E
FAU - Yuan, W
AU  - Yuan W
FAU - Wagner, S N
AU  - Wagner SN
FAU - Barrera, J L
AU  - Barrera JL
FAU - Mohar, A
AU  - Mohar A
FAU - Verastegui, E
AU  - Verastegui E
FAU - Zlotnik, A
AU  - Zlotnik A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Nature
JT  - Nature
JID - 0410462
RN  - 0 (Actins)
RN  - 0 (Blood Proteins)
RN  - 0 (CCR7 protein, human)
RN  - 0 (CXCL12 protein, human)
RN  - 0 (Ccr7 protein, mouse)
RN  - 0 (Chemokine CXCL12)
RN  - 0 (Chemokines, CXC)
RN  - 0 (Cxcl12 protein, mouse)
RN  - 0 (Receptors, CCR7)
RN  - 0 (Receptors, CXCR4)
RN  - 0 (Receptors, Chemokine)
SB  - IM
CIN - Nature. 2001 Mar 1;410(6824):24-5. PMID: 11242022
MH  - Actins/metabolism
MH  - Animals
MH  - Blood Proteins/metabolism
MH  - Breast Neoplasms/*pathology
MH  - Chemokine CXCL12
MH  - Chemokines, CXC/*metabolism
MH  - Chemotaxis
MH  - Humans
MH  - Lung/pathology
MH  - Lymphatic Metastasis
MH  - Mice
MH  - Mice, SCID
MH  - Neoplasm Invasiveness
MH  - *Neoplasm Metastasis
MH  - Neoplasm Transplantation
MH  - Receptors, CCR7
MH  - Receptors, CXCR4/antagonists & inhibitors/*metabolism
MH  - Receptors, Chemokine/*metabolism
MH  - Tumor Cells, Cultured
EDAT- 2001/03/10 10:00
MHDA- 2001/04/03 10:01
CRDT- 2001/03/10 10:00
PHST- 2001/03/10 10:00 [pubmed]
PHST- 2001/04/03 10:01 [medline]
PHST- 2001/03/10 10:00 [entrez]
AID - 35065016 [pii]
AID - 10.1038/35065016 [doi]
PST - ppublish
SO  - Nature. 2001 Mar 1;410(6824):50-6. doi: 10.1038/35065016.