PMID- 11244051
OWN - NLM
STAT- MEDLINE
DCOM- 20010802
LR  - 20220408
IS  - 0732-0582 (Print)
IS  - 0732-0582 (Linking)
VI  - 19
DP  - 2001
TI  - Interleukin-10 and the interleukin-10 receptor.
PG  - 683-765
AB  - Interleukin-10 (IL-10), first recognized for its ability to inhibit activation 
      and effector function of T cells, monocytes, and macrophages, is a 
      multifunctional cytokine with diverse effects on most hemopoietic cell types. The 
      principal routine function of IL-10 appears to be to limit and ultimately 
      terminate inflammatory responses. In addition to these activities, IL-10 
      regulates growth and/or differentiation of B cells, NK cells, cytotoxic and 
      helper T cells, mast cells, granulocytes, dendritic cells, keratinocytes, and 
      endothelial cells. IL-10 plays a key role in differentiation and function of a 
      newly appreciated type of T cell, the T regulatory cell, which may figure 
      prominently in control of immune responses and tolerance in vivo. Uniquely among 
      hemopoietic cytokines, IL-10 has closely related homologs in several virus 
      genomes, which testify to its crucial role in regulating immune and inflammatory 
      responses. This review highlights findings that have advanced our understanding 
      of IL-10 and its receptor, as well as its in vivo function in health and disease.
FAU - Moore, K W
AU  - Moore KW
AD  - Department of Molecular Biology, DNAX Research Institute of Molecular and 
      Cellular Biology Inc., Palo Alto, California 94304, USA. kevin.moore@dnax.org
FAU - de Waal Malefyt, R
AU  - de Waal Malefyt R
FAU - Coffman, R L
AU  - Coffman RL
FAU - O'Garra, A
AU  - O'Garra A
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Annu Rev Immunol
JT  - Annual review of immunology
JID - 8309206
RN  - 0 (BCRF1 protein, Human herpesvirus 4)
RN  - 0 (Receptors, Interleukin)
RN  - 0 (Receptors, Interleukin-10)
RN  - 0 (Transcription Factors)
RN  - 0 (Viral Proteins)
RN  - 130068-27-8 (Interleukin-10)
RN  - EC 2.7.10.1 (Protein-Tyrosine Kinases)
SB  - IM
MH  - Animals
MH  - Autoimmune Diseases/genetics/immunology
MH  - Clinical Trials as Topic
MH  - Clinical Trials, Phase II as Topic
MH  - Dendritic Cells/immunology
MH  - Diabetes Mellitus, Type 1/immunology
MH  - Disease Models, Animal
MH  - Encephalomyelitis, Autoimmune, Experimental/immunology
MH  - Gene Expression Regulation
MH  - Herpesviridae/physiology
MH  - Humans
MH  - Infections
MH  - Inflammation
MH  - Interleukin-10/genetics/*physiology/therapeutic use
MH  - Lupus Erythematosus, Systemic/genetics/immunology
MH  - Lymphocyte Subsets/immunology
MH  - Mice
MH  - Mice, Inbred NOD
MH  - Mice, Inbred NZB
MH  - Mice, Knockout
MH  - Neoplasms/immunology
MH  - Neutrophils/immunology
MH  - Primates
MH  - Protein-Tyrosine Kinases/physiology
MH  - Receptors, Interleukin/genetics/*physiology
MH  - Receptors, Interleukin-10
MH  - Signal Transduction
MH  - Transcription Factors/physiology
MH  - Transcription, Genetic
MH  - Viral Proteins/physiology
RF  - 661
EDAT- 2001/03/13 10:00
MHDA- 2001/08/03 10:01
CRDT- 2001/03/13 10:00
PHST- 2001/03/13 10:00 [pubmed]
PHST- 2001/08/03 10:01 [medline]
PHST- 2001/03/13 10:00 [entrez]
AID - 19/1/683 [pii]
AID - 10.1146/annurev.immunol.19.1.683 [doi]
PST - ppublish
SO  - Annu Rev Immunol. 2001;19:683-765. doi: 10.1146/annurev.immunol.19.1.683.