PMID- 11311989
OWN - NLM
STAT- MEDLINE
DCOM- 20010726
LR  - 20191104
IS  - 0169-409X (Print)
IS  - 0169-409X (Linking)
VI  - 47
IP  - 2-3
DP  - 2001 Apr 25
TI  - Roles of lipid polymorphism in intracellular delivery.
PG  - 139-48
AB  - Lipids, which adopt nonbilayer phases, have fascinated researchers as to the 
      functional roles of these components in biomembranes. In particular, lipids 
      capable of adopting the hexagonal H(II) phase have received considerable 
      attention because of the observation that such lipids can promote membrane 
      fusion. In the rational design of lipid-based delivery systems, H(II) phase 
      lipids have been employed to endow systems with fusogenic, membrane-destabilizing 
      properties. We will outline the molecular basis for the polymorphic phase 
      behavior of lipids and highlight some of the uses of nonbilayer lipids in the 
      preparation of lipid-based delivery systems. In addition, a distinction will be 
      drawn between lipid-based systems which rely on the inclusion of nonbilayer 
      lipids for activity, and systems which contain components which actively promote 
      formation of nonbilayer structure within biological membranes.
FAU - Hafez, I M
AU  - Hafez IM
AD  - Department of Biochemistry and Molecular Biology, University of British Columbia, 
      2146 Health Sciences Mall, British Columbia V6T 1Z3, Vancouver, Canada.
FAU - Cullis, P R
AU  - Cullis PR
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Netherlands
TA  - Adv Drug Deliv Rev
JT  - Advanced drug delivery reviews
JID - 8710523
RN  - 0 (1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine)
RN  - 0 (Glycerophospholipids)
RN  - 0 (Lipid Bilayers)
RN  - 0 (Lipids)
RN  - 0 (Liposomes)
RN  - 0 (Membrane Lipids)
RN  - 0 (Micelles)
RN  - 0 (Phosphatidylethanolamines)
SB  - IM
MH  - Glycerophospholipids/*chemistry/metabolism
MH  - Hydrogen-Ion Concentration
MH  - Lipid Bilayers/*chemistry/metabolism
MH  - Lipid Metabolism
MH  - Lipids/chemistry
MH  - Liposomes
MH  - *Membrane Fusion/physiology
MH  - Membrane Lipids/*chemistry/metabolism
MH  - *Micelles
MH  - *Phosphatidylethanolamines
RF  - 78
EDAT- 2001/04/20 10:00
MHDA- 2001/07/28 10:01
CRDT- 2001/04/20 10:00
PHST- 2001/04/20 10:00 [pubmed]
PHST- 2001/07/28 10:01 [medline]
PHST- 2001/04/20 10:00 [entrez]
AID - S0169-409X(01)00103-X [pii]
AID - 10.1016/s0169-409x(01)00103-x [doi]
PST - ppublish
SO  - Adv Drug Deliv Rev. 2001 Apr 25;47(2-3):139-48. doi: 
      10.1016/s0169-409x(01)00103-x.