PMID- 11427719
OWN - NLM
STAT- MEDLINE
DCOM- 20010809
LR  - 20201222
IS  - 0027-8424 (Print)
IS  - 1091-6490 (Electronic)
IS  - 0027-8424 (Linking)
VI  - 98
IP  - 14
DP  - 2001 Jul 3
TI  - A cytomegalovirus-encoded inhibitor of apoptosis that suppresses caspase-8 
      activation.
PG  - 7829-34
AB  - We have identified a human cytomegalovirus cell-death suppressor, denoted vICA, 
      encoded by the viral UL36 gene. vICA inhibits Fas-mediated apoptosis by binding 
      to the pro-domain of caspase-8 and preventing its activation. vICA does not share 
      significant sequence homology with FLIPs or other known suppressors of apoptosis, 
      suggesting that this protein represents a new class of cell-death suppressors. 
      Notably, resistance to Fas-mediated apoptosis is delayed in fibroblasts infected 
      with viruses that encode mutant vICA, suggesting that vICA suppresses 
      death-receptor-induced cell death in the context of viral infection. Although 
      vICA is dispensable for viral replication in vitro, the common targeting of 
      caspase-8 activation by diverse herpesviruses argues for an important role for 
      this antiapoptotic mechanism in the pathogenesis of viral infection in the host, 
      most likely in avoiding immune clearance by cytotoxic lymphocytes and natural 
      killer cells.
FAU - Skaletskaya, A
AU  - Skaletskaya A
AD  - ImmunoGen, 128 Sidney Street, Cambridge, MA 02139, USA.
FAU - Bartle, L M
AU  - Bartle LM
FAU - Chittenden, T
AU  - Chittenden T
FAU - McCormick, A L
AU  - McCormick AL
FAU - Mocarski, E S
AU  - Mocarski ES
FAU - Goldmacher, V S
AU  - Goldmacher VS
LA  - eng
PT  - Journal Article
DEP - 20010626
PL  - United States
TA  - Proc Natl Acad Sci U S A
JT  - Proceedings of the National Academy of Sciences of the United States of America
JID - 7505876
RN  - 0 (UL36 protein, Human herpesvirus 1)
RN  - 0 (Viral Proteins)
RN  - EC 3.4.22.- (CASP8 protein, human)
RN  - EC 3.4.22.- (CASP9 protein, human)
RN  - EC 3.4.22.- (Caspase 8)
RN  - EC 3.4.22.- (Caspase 9)
RN  - EC 3.4.22.- (Caspases)
SB  - IM
MH  - Amino Acid Sequence
MH  - Apoptosis/*genetics
MH  - Caspase 8
MH  - Caspase 9
MH  - Caspases/*genetics
MH  - Cell Line
MH  - Cytomegalovirus/*genetics
MH  - Cytomegalovirus Infections/*genetics/*pathology
MH  - Enzyme Activation/genetics
MH  - Gene Expression Regulation, Viral
MH  - Humans
MH  - Molecular Sequence Data
MH  - Signal Transduction/genetics
MH  - Viral Proteins/*genetics
PMC - PMC35427
EDAT- 2001/06/28 10:00
MHDA- 2001/08/10 10:01
PMCR- 2002/01/03
CRDT- 2001/06/28 10:00
PHST- 2001/06/28 10:00 [pubmed]
PHST- 2001/08/10 10:01 [medline]
PHST- 2001/06/28 10:00 [entrez]
PHST- 2002/01/03 00:00 [pmc-release]
AID - 141108798 [pii]
AID - 1087 [pii]
AID - 10.1073/pnas.141108798 [doi]
PST - ppublish
SO  - Proc Natl Acad Sci U S A. 2001 Jul 3;98(14):7829-34. doi: 10.1073/pnas.141108798. 
      Epub 2001 Jun 26.