PMID- 11455617
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20051116
IS  - 1059-910X (Print)
IS  - 1059-910X (Linking)
VI  - 54
IP  - 2
DP  - 2001 Jul 15
TI  - Role of microglia in glioma biology.
PG  - 106-13
AB  - Microglia, a type of differentiated tissue macrophage, are considered to be the 
      most plastic cell population of the central nervous system (CNS). In response to 
      pathological conditions, resting microglia undergo a stereotypic activation 
      process and become capable of phagocytosis, antigen presentation, and lymphocyte 
      activation. Considering their immune effector function, it is not surprising to 
      see microglia accumulation in almost every CNS disease process, including 
      malignant brain tumors or malignant gliomas. Although the function of these cells 
      in CNS inflammatory processes is being studied, their role in malignant glioma 
      biology remains unclear. On one hand, microglia may represent a CNS anti-tumor 
      response, which is inactivated by local secretion of immunosuppressive factors by 
      glioma cells. On the other hand, taking into account that microglia are capable 
      of secreting a variety of immunomodulatory cytokines, it is possible that they 
      are attracted by gliomas to promote tumor growth. A better understanding of 
      microglia-glioma interaction will be helpful in designing novel immune-based 
      therapies against these fatal tumors.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Badie, B
AU  - Badie B
AD  - Neuro-oncology Laboratory, Department of Neurological Surgery, University of 
      Wisconsin School of Medicine, Madison, Wisconsin 53792, USA. 
      badie@neurosurg.wisc.edu
FAU - Schartner, J
AU  - Schartner J
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Microsc Res Tech
JT  - Microscopy research and technique
JID - 9203012
SB  - IM
MH  - Animals
MH  - Brain Neoplasms/*pathology/*physiopathology
MH  - Glioma/*pathology/*physiopathology
MH  - Humans
MH  - Microglia/*physiology
MH  - Rats
RF  - 50
EDAT- 2001/07/17 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/07/17 10:00
PHST- 2001/07/17 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/07/17 10:00 [entrez]
AID - 10.1002/jemt.1125 [pii]
AID - 10.1002/jemt.1125 [doi]
PST - ppublish
SO  - Microsc Res Tech. 2001 Jul 15;54(2):106-13. doi: 10.1002/jemt.1125.