PMID- 11489482
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20220330
IS  - 0168-3659 (Print)
IS  - 0168-3659 (Linking)
VI  - 74
IP  - 1-3
DP  - 2001 Jul 6
TI  - Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR 
      effect in solid tumor and clinical overview of the prototype polymeric drug 
      SMANCS.
PG  - 47-61
AB  - This review article describes three aspects of polymeric drugs. The general 
      mechanism of the EPR (enhanced permeability and retention) effect and factors 
      involved in the effect are discussed, in view of the advantages of macromolecular 
      therapeutics for cancer treatment, which are based on the highly selective 
      EPR-related delivery of drug to tumor. Also described are advantages of more 
      general water-soluble polymeric drugs as primary anticancer agents, using SMANCS 
      as an example. Last, SMANCS/Lipiodol is discussed with reference to the type of 
      formulation for arterial injection with most pronounced tumor selective delivery, 
      as well as its advantages, precautions, and side effects from the clinical 
      standpoint.
FAU - Maeda, H
AU  - Maeda H
AD  - Department of Microbiology, Kumamoto University School of Medicine, 860-0811, 
      Kumamoto, Japan. msmaedah@gpo.kumamoto-u.ac.jp
FAU - Sawa, T
AU  - Sawa T
FAU - Konno, T
AU  - Konno T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Macromolecular Substances)
RN  - 0 (Maleic Anhydrides)
RN  - 0 (Polystyrenes)
RN  - 0 (poly(maleic acid-styrene)neocarzinostatin)
RN  - 9014-02-2 (Zinostatin)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Antineoplastic Agents/administration & dosage/pharmacokinetics/*pharmacology
MH  - *Drug Delivery Systems
MH  - Humans
MH  - Macromolecular Substances
MH  - Maleic Anhydrides/administration & dosage/pharmacokinetics/*pharmacology
MH  - Molecular Sequence Data
MH  - Permeability
MH  - Polystyrenes/administration & dosage/pharmacokinetics/*pharmacology
MH  - Zinostatin/administration & dosage/*analogs & 
      derivatives/pharmacokinetics/*pharmacology
RF  - 49
EDAT- 2001/08/08 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/08/08 10:00
PHST- 2001/08/08 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/08/08 10:00 [entrez]
AID - S0168365901003091 [pii]
AID - 10.1016/s0168-3659(01)00309-1 [doi]
PST - ppublish
SO  - J Control Release. 2001 Jul 6;74(1-3):47-61. doi: 10.1016/s0168-3659(01)00309-1.