PMID- 11535634
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20220318
IS  - 0022-1007 (Print)
IS  - 1540-9538 (Electronic)
IS  - 0022-1007 (Linking)
VI  - 194
IP  - 5
DP  - 2001 Sep 3
TI  - A pathogenic role for myelin-specific CD8(+) T cells in a model for multiple 
      sclerosis.
PG  - 669-76
AB  - Multiple sclerosis (MS) is a demyelinating disease of the central nervous system 
      (CNS) characterized by plaques of infiltrating CD4(+) and CD8(+) T cells. Studies 
      of MS and experimental autoimmune encephalomyelitis (EAE), an animal model of MS, 
      focus on the contribution of CD4(+) myelin-specific T cells. The role of CD8(+) 
      myelin-specific T cells in mediating EAE or MS has not been described previously. 
      Here, we demonstrate that myelin-specific CD8(+) T cells induce severe CNS 
      autoimmunity in mice. The pathology and clinical symptoms in CD8(+) T 
      cell-mediated CNS autoimmunity demonstrate similarities to MS not seen in 
      myelin-specific CD4(+) T cell-mediated EAE. These data suggest that 
      myelin-specific CD8(+) T cells could function as effector cells in the 
      pathogenesis of MS.
FAU - Huseby, E S
AU  - Huseby ES
AD  - Department of Immunology, University of Washington, Seattle, Washington 98195, 
      USA.
FAU - Liggitt, D
AU  - Liggitt D
FAU - Brabb, T
AU  - Brabb T
FAU - Schnabel, B
AU  - Schnabel B
FAU - Ohlen, C
AU  - Ohlen C
FAU - Goverman, J
AU  - Goverman J
LA  - eng
GR  - T32 CA009537/CA/NCI NIH HHS/United States
GR  - CA09537-13/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - J Exp Med
JT  - The Journal of experimental medicine
JID - 2985109R
RN  - 0 (Myelin Basic Protein)
SB  - IM
CIN - J Exp Med. 2001 Sep 3;194(5):F27-30. PMID: 11535639
MH  - Adoptive Transfer
MH  - Animals
MH  - Autoimmunity
MH  - Brain/*immunology/pathology/physiopathology
MH  - CD4-Positive T-Lymphocytes/immunology/pathology
MH  - CD8-Positive T-Lymphocytes/*immunology/pathology
MH  - Clone Cells
MH  - Disease Models, Animal
MH  - Mice
MH  - Mice, Inbred C3H
MH  - Mice, Inbred MRL lpr
MH  - Mice, SCID
MH  - Multiple Sclerosis/*immunology/pathology/physiopathology
MH  - Myelin Basic Protein/*immunology
MH  - Spinal Cord/*immunology/pathology/physiopathology
MH  - T-Lymphocytes/immunology
MH  - Time Factors
PMC - PMC2195947
EDAT- 2001/09/06 10:00
MHDA- 2001/10/12 10:01
PMCR- 2002/03/03
CRDT- 2001/09/06 10:00
PHST- 2001/09/06 10:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2001/09/06 10:00 [entrez]
PHST- 2002/03/03 00:00 [pmc-release]
AID - 010250 [pii]
AID - 10.1084/jem.194.5.669 [doi]
PST - ppublish
SO  - J Exp Med. 2001 Sep 3;194(5):669-76. doi: 10.1084/jem.194.5.669.