PMID- 11596126
OWN - NLM
STAT- MEDLINE
DCOM- 20020104
LR  - 20220311
IS  - 0894-1491 (Print)
IS  - 0894-1491 (Linking)
VI  - 36
IP  - 2
DP  - 2001 Nov
TI  - Immune function of astrocytes.
PG  - 180-90
AB  - Astrocytes are the major glial cell within the central nervous system (CNS) and 
      have a number of important physiological properties related to CNS homeostasis. 
      The aspect of astrocyte biology addressed in this review article is the astrocyte 
      as an immunocompetent cell within the brain. The capacity of astrocytes to 
      express class II major histocompatibility complex (MHC) antigens and 
      costimulatory molecules (B7 and CD40) that are critical for antigen presentation 
      and T-cell activation are discussed. The functional role of astrocytes as immune 
      effector cells and how this may influence aspects of inflammation and immune 
      reactivity within the brain follows, emphasizing the involvement of astrocytes in 
      promoting Th2 responses. The ability of astrocytes to produce a wide array of 
      chemokines and cytokines is discussed, with an emphasis on the immunological 
      properties of these mediators. The significance of astrocytic antigen 
      presentation and chemokine/cytokine production to neurological diseases with an 
      immunological component is described.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Dong, Y
AU  - Dong Y
AD  - Department of Cell Biology, University of Alabama at Birmingham, Birmingham, 
      Alabama 35294-0005, USA.
FAU - Benveniste, E N
AU  - Benveniste EN
LA  - eng
GR  - MH-55795/MH/NIMH NIH HHS/United States
GR  - NS-29719/NS/NINDS NIH HHS/United States
GR  - NS-34856/NS/NINDS NIH HHS/United States
GR  - NS-36765/NS/NINDS NIH HHS/United States
GR  - NS-39954/NS/NINDS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PT  - Review
PL  - United States
TA  - Glia
JT  - Glia
JID - 8806785
RN  - 0 (Chemokine CCL2)
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class II)
RN  - 0 (Interleukin-6)
RN  - 0 (MHC class II transactivator protein)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Trans-Activators)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/immunology
MH  - Astrocytes/cytology/*immunology
MH  - Central Nervous System/cytology/*immunology
MH  - Chemokine CCL2/immunology/metabolism
MH  - Cytokines/immunology/metabolism
MH  - Histocompatibility Antigens Class II/immunology
MH  - Humans
MH  - Interleukin-6/immunology/metabolism
MH  - *Nuclear Proteins
MH  - T-Lymphocytes/cytology/*immunology
MH  - Trans-Activators/genetics/immunology/metabolism
RF  - 134
EDAT- 2001/10/12 10:00
MHDA- 2002/01/10 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2002/01/10 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
AID - 10.1002/glia.1107 [pii]
AID - 10.1002/glia.1107 [doi]
PST - ppublish
SO  - Glia. 2001 Nov;36(2):180-90. doi: 10.1002/glia.1107.