PMID- 11801451
OWN - NLM
STAT- MEDLINE
DCOM- 20020510
LR  - 20191105
IS  - 1471-4906 (Print)
IS  - 1471-4906 (Linking)
VI  - 23
IP  - 1
DP  - 2002 Jan
TI  - Immunology of viral-vector-mediated gene transfer into the brain: an evolutionary 
      and developmental perspective.
PG  - 23-30
AB  - The immune system imposes limitations on gene transfer into the brain. Viral 
      vectors injected into the brain's ventricular system elicit innate and adaptive 
      immune responses. However, when injected directly into the brain parenchyma, they 
      elicit only transient inflammation owing to the absence of dendritic cells, which 
      transport antigen to lymph nodes and present it to naive T cells to initiate 
      adaptive immune responses. This article explores the evolutionary and 
      developmental basis of brain immune responses and their implications for 
      viral-vector-mediated neurological gene therapy. Elucidating the cellular and 
      molecular basis of these differential reactions is essential to the long-term 
      success of neurological gene therapy.
FAU - Lowenstein, Pedro R
AU  - Lowenstein PR
AD  - Gene Therapeutics Research Institute, Cedars-Sinai Medical Center, Research 
      Pavilion, Room 5093, 8700 Beverly Blvd, Los Angeles, CA 90048, USA. 
      lowensteinp@cshs.org
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - Trends Immunol
JT  - Trends in immunology
JID - 100966032
SB  - IM
CIN - Trends Immunol. 2002 Feb;23(2):69-70; author reply 70. PMID: 11929128
MH  - Animals
MH  - Biological Evolution
MH  - Brain/*immunology
MH  - *Gene Transfer Techniques
MH  - Genetic Vectors/*immunology
MH  - Immune System/*physiology
MH  - Immune Tolerance
MH  - Inflammation/immunology
MH  - Phylogeny
MH  - Viruses/*genetics
RF  - 57
EDAT- 2002/01/22 10:00
MHDA- 2002/05/11 10:01
CRDT- 2002/01/22 10:00
PHST- 2002/01/22 10:00 [pubmed]
PHST- 2002/05/11 10:01 [medline]
PHST- 2002/01/22 10:00 [entrez]
AID - S1471490601020634 [pii]
AID - 10.1016/s1471-4906(01)02063-4 [doi]
PST - ppublish
SO  - Trends Immunol. 2002 Jan;23(1):23-30. doi: 10.1016/s1471-4906(01)02063-4.