PMID- 11856529
OWN - NLM
STAT- MEDLINE
DCOM- 20020321
LR  - 20211203
IS  - 0896-6273 (Print)
IS  - 0896-6273 (Linking)
VI  - 33
IP  - 4
DP  - 2002 Feb 14
TI  - wishful thinking encodes a BMP type II receptor that regulates synaptic growth in 
      Drosophila.
PG  - 545-58
AB  - We conducted a large-scale screen for Drosophila mutants that have structural 
      abnormalities of the larval neuromuscular junction (NMJ). We recovered mutations 
      in wishful thinking (wit), a gene that positively regulates synaptic growth. wit 
      encodes a BMP type II receptor. In wit mutant larvae, the size of the NMJs is 
      greatly reduced relative to the size of the muscles. wit NMJs have reduced evoked 
      excitatory junctional potentials, decreased levels of the synaptic cell adhesion 
      molecule Fasciclin II, and synaptic membrane detachment at active zones. Wit is 
      expressed by a subset of neurons, including motoneurons. The NMJ phenotype is 
      specifically rescued by transgenic expression of Wit only in motoneurons. Thus, 
      Wit appears to function as a presynaptic receptor that regulates synaptic size at 
      the Drosophila NMJ.
FAU - Aberle, Hermann
AU  - Aberle H
AD  - Howard Hughes Medical Institute, Department of Molecular and Cell Biology, 
      University of California, Berkeley, CA 94720, USA.
FAU - Haghighi, A Pejmun
AU  - Haghighi AP
FAU - Fetter, Richard D
AU  - Fetter RD
FAU - McCabe, Brian D
AU  - McCabe BD
FAU - Magalhaes, Tiago R
AU  - Magalhaes TR
FAU - Goodman, Corey S
AU  - Goodman CS
LA  - eng
SI  - GENBANK/AF420466
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuron
JT  - Neuron
JID - 8809320
RN  - 0 (Bone Morphogenetic Proteins)
RN  - 0 (Drosophila Proteins)
RN  - 0 (Elapid Venoms)
RN  - 0 (Neurotransmitter Agents)
RN  - 86697-68-9 (fasciculin)
RN  - EC 2.7.11.1 (Protein Serine-Threonine Kinases)
RN  - EC 2.7.11.30 (Bone Morphogenetic Protein Receptors, Type II)
SB  - IM
CIN - Neuron. 2002 Feb 14;33(4):491-2. PMID: 11856522
CIN - Neuron. 2010 May 27;66(4):473-5. PMID: 20510851
MH  - Animals
MH  - Animals, Genetically Modified/abnormalities/growth & development/metabolism
MH  - Body Patterning/*genetics
MH  - Bone Morphogenetic Protein Receptors, Type II
MH  - Bone Morphogenetic Proteins/genetics/metabolism
MH  - Cell Adhesion/genetics
MH  - Central Nervous System/*abnormalities/growth & development/ultrastructure
MH  - Down-Regulation/genetics
MH  - Drosophila Proteins/*genetics/isolation & purification
MH  - Drosophila melanogaster/*embryology/growth & development/ultrastructure
MH  - Elapid Venoms/metabolism
MH  - Female
MH  - Gene Expression Regulation, Developmental/*physiology
MH  - Genetic Testing
MH  - Male
MH  - Molecular Sequence Data
MH  - Mutation/*genetics
MH  - Neuromuscular Junction/*abnormalities/growth & development/ultrastructure
MH  - Neuronal Plasticity/genetics
MH  - Neurotransmitter Agents/genetics/metabolism
MH  - Protein Serine-Threonine Kinases/*genetics/isolation & purification
MH  - Sequence Homology, Amino Acid
MH  - Sequence Homology, Nucleic Acid
MH  - Signal Transduction/genetics
MH  - Synaptic Membranes/genetics/metabolism/ultrastructure
EDAT- 2002/02/22 10:00
MHDA- 2002/03/22 10:01
CRDT- 2002/02/22 10:00
PHST- 2002/02/22 10:00 [pubmed]
PHST- 2002/03/22 10:01 [medline]
PHST- 2002/02/22 10:00 [entrez]
AID - S0896627302005895 [pii]
AID - 10.1016/s0896-6273(02)00589-5 [doi]
PST - ppublish
SO  - Neuron. 2002 Feb 14;33(4):545-58. doi: 10.1016/s0896-6273(02)00589-5.